AJTMH ASTMH MEMBERSHIP INFORMATION: astmh@astmh.org
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 74(3), 2006, pp. 425-431
Copyright © 2006 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (2)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by BOUSEMA, J. T.
Right arrow Articles by SAUERWEIN, R. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by BOUSEMA, J. T.
Right arrow Articles by SAUERWEIN, R. W.
Related Collections
Right arrow Immunology
Right arrow Malaria

RAPID ONSET OF TRANSMISSION-REDUCING ANTIBODIES IN JAVANESE MIGRANTS EXPOSED TO MALARIA IN PAPUA, INDONESIA

J. TEUN BOUSEMA*,{dagger}, WILL ROEFFEN{dagger}, MIKE VAN DER KOLK{dagger}, SAKE J. DE VLAS, MARGA VAN DE VEGTE-BOLMER, MICHAEL J. BANGS, KARINA TEELEN, LILIANA KURNIAWAN, JASON D. MAGUIRE, J. KEVIN BAIRD, AND ROBERT W. SAUERWEIN
Department of Medical Microbiology, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands; Department of Public Health, Erasmus Medical Centre, University Medical Center Rotterdam, The Netherlands; U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia; National Institute of Health Research and Development, Jakarta, Indonesia

Transmission of Plasmodium falciparum malaria is initiated by sexual stages in the mosquito. Anti-Pfs48/45 and anti-Pfs230 sexual stage antibodies that are ingested together with parasites can reduce parasite development and subsequently malaria transmission. Acquisition of sexual stage immunity was studied in a cohort of 102 non-immune Javanese individuals migrating to hyperendemic Papua Indonesia. Seroprevalence of antibodies against Pfs48/45 and Pfs230 and functional transmission-reducing activity (TRA) were measured upon arrival and at 6, 12, and 24 months. Asexual parasitemia and gametocytemia were assessed every two weeks. The TRA and seroreactivity increased with the number of P. falciparum infections. The longitudinally sustained association between TRA and antibodies against Pfs48/45 (odds ratio [OR] = 3.74, 95% confidence interval [CI] = 1.51–9.29) and Pfs230 (OR = 3.72, 95% CI = 1.36–10.17) suggests that functional transmission reducing immunity is acquired after limited exposure to infection.

Received September 9, 2005. Accepted for publication October 20, 2005.

Acknowledgments: We thank all the residents from SP2 for their participation in this study; the Ministry of Health in Jakarta and the Provincial Health Service of Papua in Jayapura for their support; the collaborating technicians and assistants at SP2 for a wonderful job during follow-up of participating volunteers; G. J. van Gemert for performing parasite cultures and transmission experiments; and J. P. Verhave for starting the original collaboration.

Financial support: Work in The Netherlands was supported by NWO-WOTRO (WM 93-350; 2003-00702), and European Community KA2 programme 1999–2003. Work in Indonesia was supported by the Department of Defense Medical Infectious Diseases Research Program.

Disclaimer: The views and opinions are those of the authors and do not purport those of the U.S. Navy or Department of Defense.

* Address correspondence to J. Teun Bousema, Department of Medical Microbiology 268, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. E-mail: t.bousema{at}ncmls.ru.nl

{dagger} These authors contributed equally to this work.

Authors’ addresses: J. Teun Bousema, Will Roeffen, Mike van der Kolk, Marga van der Vegte-Bolmer, Karina Teelen, and Robert W Sauerwein, Department of Medical Mirobiology 188, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands, Telephone: 31-24-361-9515, Fax: 31-24-361-4666. Sake J. de Vlas, Department of Public Health, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands, Telephone: 31-10-408-8285, Fax: 31-10-408-9449. Michael J. Bangs, Jason D. Maguire, and J. Kevin Baird, U.S. Naval Medical Research Unit No. 2, FPO, AP 96520-8132 or JI Percetakan Negara No. 29, Jakarta 10560, Indonesia. Liliana Kurniawan, National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia.

Reprint requests: Robert W. Sauerwein, Department of Medical Microbiology 268, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands, Telephone: 31-24-361-4306, Fax: 31-24-361-4666, E-mail: r.sauerwein{at}mmb.umcn.nl.




This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
N. S. Outchkourov, W. Roeffen, A. Kaan, J. Jansen, A. Luty, D. Schuiffel, G. J. van Gemert, M. van de Vegte-Bolmer, R. W. Sauerwein, and H. G. Stunnenberg
Correctly folded Pfs48/45 protein of Plasmodium falciparum elicits malaria transmission-blocking immunity in mice
PNAS, March 18, 2008; 105(11): 4301 - 4305.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2006 by the American Society of Tropical Medicine and Hygiene.