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Am. J. Trop. Med. Hyg., 74(2), 2006, pp. 342-344
Copyright © 2006 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT


FAILURE OF STANDARD TREATMENT WITH PRAZIQUANTEL IN TWO RETURNED TRAVELERS WITH SCHISTOSOMA HAEMATOBIUM INFECTION

DAVID ALONSO*, JOSE MUÑOZ, JOAQUIM GASCÓN, MARIA EUGENIA VALLS, AND MANUEL CORACHAN
International Health Center, e Servicio de Microbiología Centro de Diagnóstico Biomédico Clínic, Institut d’Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain

 

ABSTRACT

A single 40 mg/kg dose of praziquantel (PZQ) continues to be the standard treatment for schistosomiasis caused by S. mansoni and S. haematobium in all clinical settings. Experimental development of drug resistance and the recent isolation of S. mansoni strains with a natural tolerance to high doses of PZQ have raised concerns over the adequacy of such a dose. We describe two Spanish travelers with genitourinary schistosomiasis caused by S. haematobium in whom repeated standard treatment failed to clear the infection.

Received August 5, 2005. Accepted for publication August 26, 2005.

Acknowledgments: This study has been developed as part of the Red de Centros de Investigación Cooperativa en Epidemiologia Y Salud Pública (RICET)/Red de Investigación de Centros de Enfermedodes Tropicales (RCESP) research program.

* Address correspondence to David Alonso, Centre de Salut Internacional, c/Rosello 132 2° 2a 08036, Hospital Clinic, Barcelona, Spain.

Authors’ addresses: David Alonso, Jose Muñoz, Joaquim Gascón, and Manuel Corachan, Centre de Salut Internacional, c/Rosello 132 2° 2ª 08036, Hospital Clinic, Barcelona, Spain, Telephone: 34-9-3227-5400 extension 3322, Fax: 34-9-3227-9853, E-mail: cojup99{at}hotmail.com. Maria Eugenia Valls, Sevicio de Microbiologia, Centro de Diagnóstico Biomédico Clínic, Institut d’Investigacions Bio-mediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain.




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