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Am. J. Trop. Med. Hyg., 74(2), 2006, pp. 239-245
Copyright © 2006 by The American Society of Tropical Medicine and Hygiene

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MORBIDITY AND MORTALITY PROFILE OF HUMAN IMMUNODEFICIENCY VIRUS–INFECTED PATIENTS WITH AND WITHOUT HEPATITIS C CO-INFECTION

ANGEL M. MAYOR*, MARIA A. GOMEZ, DIANA M. FERNANDEZ, EDDY RIOS-OLIVARES, JAMES C. THOMAS, AND ROBERT F. HUNTER
Retrovirus Research Center, and Department of Microbiology, Universidad Central del Caribe, School of Medicine, Bayamón, Puerto Rico; Epidemiology Department, School of Public Health, University of North Carolina, Chapel Hill, North Carolina

Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) co-infection is an important and frequent scenario, predominantly in injecting drug users (IDUs). The present study evaluated morbidity and mortality variation in HIV-infected patients with and without HCV co-infection. Co-infection prevalence was determined in 356 HIV-infected persons. Their clinical manifestations, laboratory findings, risk factors, HIV therapies, and mortality rates were evaluated. The prevalence of HCV was 54% in the overall group and 81% in IDUs, with a predominance of HCV genotype 1. Mortality rates were similar in patients with and without co-infection; however, co-infected patients had significantly higher liver damage as a cause of mortality when compared with those who were not co-infected. The high prevalence of HCV and an emerging mortality from liver diseases showed the significance of this co-infection in the HIV epidemic. Primary and secondary prevention are necessary to reduce the expanding impact of HCV infection in HIV patients.

Received January 19, 2005. Accepted for publication September 28, 2005.

Acknowledgments: We thank the Puerto Rican Demographic register for its help and collaboration.

Financial support: This study was supported by RCMI/NIH grants G12RR03035 and 1U54RR01950701, and by Centers for Disease Control and Prevention Adult Spectrum of Disease grant U62/CCU206209.

* Address correspondence to Angel M. Mayor, Retrovirus Research Center, Universidad Central del Caribe School of Medicine, P.O. Box 60327, Bayamón, PR 00960-6032. E-mail: amayorb{at}hotmail.com

Authors’ addresses: Angel M. Mayor, Maria A. Gomez, Diana M. Fernandez, and Robert F. Hunter, Retrovirus Research Center, Universidad Central del Caribe, School of Medicine, P.O. Box 60327, Bayamón, PR 00960-6032, Telephone: 787-787-8710, Fax: 787-787-8733, E-mail: amayorb{at}hotmail.com. Eddy Rios-Olivares, Department of Microbiology, Universidad Central del Caribe, School of Medicine, Bayamón, PR 00960-6032. James C. Thomas, Epidemiology Department, School of Public Health, University of North Carolina, Chapel Hill, NC 27599-7435.






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Copyright © 2006 by the American Society of Tropical Medicine and Hygiene.