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ARAGUARI VIRUS, A NEW MEMBER OF THE FAMILY ORTHOMYXOVIRIDAE: SEROLOGIC, ULTRASTRUCTURAL, AND MOLECULAR CHARACTERIZATION

This paper reports the results of serologic, structural, biochemical, and genetic studies indicating that Araguari virus, a previously unassigned viral agent, is a member of the family Orthomyxoviridae and genus Thogotovirus. Araguari virus has six RNA fragments; biologically, it shares several properties with other viruses in the family Orthomyxoviridae. Nucleotide sequencing of the RNA segments 4 (glycoprotein) and 5 (nucleoprotein) of Araguari virus aligned with the orthomyxoviruses, showing the closest relationship with Thogoto virus (sequence similarity = 61.9% and 69.1%, respectively, for glycoprotein and nucleoprotein), but also sharing a more distant similarity with Dhori and Influenza C viruses, especially for the glycoprotein gene. Based on these results, we propose that Araguari virus should be assigned as a new member of the family Orthomyxoviridae and genus Thogotovirus.

Received May 20, 2005. Accepted for publication August 19, 2005.

Acknowledgments: We thank Basílio S. Buna and Helena B. Vasconcelos for their technical assistance. The GenBank accession numbers of the sequences reported in this paper are: DQ 23096–97.

Financial support: This work was supported in part by contract N01-AI30027 from the U.S. National Institute of Health, by CNPq grants 302770/02-0 and 550275/01-0, and by CAPES (Eliana V. Pinto da Silva).

^* Address correspondence to Pedro F. C. Vasconcelos, Departmento de Arbovirologia e Febres Hemorrágicas, Instituto Evandro Chagas, Avenida Almirante Barroso, 492, 66093-020, Belem, Pará, Brazil. E-mail: pedrovasconcelos{at}iec.pa.gov.br

Authors’ addresses: Eliana V. Pinto da Silva, Márcio R. T. Nunes, José A. P. Diniz, Ana C. R. Cruz, and Pedro F. C. Vasconcelos, Departmento de Arbovirologia e Febres Hemorrágicas, Instituto Evandro Chagas, Avenida Almirante Barroso, 492, 66093-020, Belem, Pará, Brazil, Telephone: 55-91-3202-4699, Fax: 55-91-3226-1284; E-mail: pedrovasconcelos{at}iec.pa.gov.br. Amelia P. A. Travassos da Rosa and Robert B. Tesh, Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555-0609. Conceição M. A. Vieira, Universidade Federal Rural da Amazônia, Belém, Pará, Brazil.

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