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Am. J. Trop. Med. Hyg., 73(5), 2005, pp. 947-948
Copyright © 2005 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT


Q FEVER PNEUMONIA: ARE CLARITHROMYCIN AND MOXIFLOXACIN ALTERNATIVE TREATMENTS ONLY?

MIRO MOROVIC*
Department for Infectious Diseases, Zadar General Hospital, Zadar, Croatia

 

ABSTRACT

Medical records of 77 patients with Q fever pneumonia that was serologically confirmed by enzyme-linked immunosorbent assay were studied to compare the clinical efficacy of doxycycline, clarithromycin, and moxifloxacin. The mean times to defervescence were 2.4 days for those receiving doxycycline, 1.9 days for those receiving clarithromycin, and 2.2 days for those receiving moxifloxacin. There were no interruptions of the regimens in any groups because of side effects, and outcome was favorable in all patients with no complications or relapses during follow-up. This efficacy of clarithromycin and moxifloxacin, together with their safety profiles, suggest that these alternative agents in the treatment of Q fever pneumonia could also be used as the first-line therapy.

Received February 11, 2005. Accepted for publication April 15, 2005.

* Address correspondence to Miro Morovic, Department for Infectious Diseases, Zadar General Hospital, Boze Pericica 5, 23000 Zadar, Croatia. E-mail: miro.morovic{at}zd.t-com.hr

Author’s address: Miro Morovic, Department for Infectious Diseases, Zadar General Hospital, Boze Pericica 5, 23000 Zadar, Croatia, E-mail: miro.morovic{at}zd.t-com.hr.






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Copyright © 2005 by the American Society of Tropical Medicine and Hygiene.