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Am. J. Trop. Med. Hyg., 73(5), 2005, pp. 855-858
Copyright © 2005 by The American Society of Tropical Medicine and Hygiene

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EVALUATION OF A RAPID DIAGNOSTIC TEST FOR ASSESSING THE BURDEN OF MALARIA AT DELIVERY IN INDIA

NEERU SINGH*, AJAY SAXENA, S. B. AWADHIA, RITA SHRIVASTAVA, AND M. P. SINGH
Malaria Research Centre, Field Station, Jabalpur, Madhya Pradesh, India; Civil Hospital Maihar, District Satna, Madhya Pradesh, India; District Hospital Mandla, Madhya Pradesh, India

All pregnant women who came for delivery at a district hospital in Mandla and a civil hospital in Maihar were screened for Plasmodium falciparum (placental parasitemia using a rapid test and microscopy and peripheral and umbilical cord parasitemia using microscopy alone). Two rapid diagnostic tests (RDTs), Paracheck Pf and ParaHITf, were used. At Mandla, the sensitivity and specificity of the Paracheck Pf for P. falciparum were 93% and 84%, respectively. The positive predictive values (PPVs) and negative predictive values (NPVs) were 50% and 99%, respectively. At Maihar, the sensitivity and specificity of the ParaHITf for P. falciparum were 87.5% and 97%, respectively. The PPVs and NPVs were 75.4% and 98.7%, respectively. Placental infection was significantly associated with low birth weight. The RDTs for the identification of P. falciparum were more sensitive in placental blood than the placental blood smear by microscopy. Thus, the RDTs should be useful for rapid assessment of malaria at delivery.

Received April 26, 2005. Accepted for publication July 6, 2005.

Acknowledgments: We thank Professor A. P. Dash (Malaria Research Centre, Delhi, Indai) for help and guidance. We also thank Span Diagnostics (Surat, India) and Orchid Biomedical Systems (Verna, Goa, India) for the test kits.

* Address correspondence to Neeru Singh, Malaria Research Centre, Field Station, Jabalpur 482003, Madhya Pradesh, India. E-mail: neeru.singh{at}gmail.com or oicmrc{at}yahoo.co.in

Authors’ addressees: Neeru Singh, Ajay Saxena, and M. P. Singh, Malaria Research Centre, Field Station, Jabalpur 482003, Madhya Pradesh, India, Telephone: 91-761-267-2973, Fax: 91-761-267-2900, E-mails: neerusingh{at}gmail.com or oicmrc{at}yahoo.co.in and mrigendrapal{at}gmail.com. S. B. Awadhia, Civil Hospital Maihar, 485771, District Satna, Madhya Pradesh, India. Rita Shrivastava, District Hospital Mandla, 481661, Madhya Pradesh, India.




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