HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (13) Citing Articles via Google Scholar Google Scholar Articles by ZONGO, I. Articles by ROSENTHAL, P. J. Search for Related Content PubMed PubMed Citation Articles by ZONGO, I. Articles by ROSENTHAL, P. J. Related Collections Drug-Resistance Malaria

AMODIAQUINE, SULFADOXINE-PYRIMETHAMINE, AND COMBINATION THERAPY FOR UNCOMPLICATED FALCIPARUM MALARIA: A RANDOMIZED CONTROLLED TRIAL FROM BURKINA FASO

Increasing resistance to chloroquine necessitates the evaluation of other antimalarial therapies in Africa. We compared the efficacies of amodiaquine (AQ), sulfadoxine-pyrimethamine (SP), and AQ + SP for the treatment of uncomplicated falciparum malaria in a randomized trial of patients 6 months of age or older in Bobo-Dioulasso, Burkina Faso. Of the 944 patients enrolled, 829 (88%; 53% under 5 years of age) were assigned 28-day efficacy outcomes. For all regimens, early treatment failures were uncommon (< 2%). Considering all treatment failures based on WHO criteria, AQ + SP was most efficacious (failures in 4.2%), followed by SP (9.1%) and AQ (17.9%; P < 0.02 for all pairwise comparisons). Considering only clinical failures, relative efficacies were similar (failures in 2.1% with AQ + SP, 6.5% with SP, and 13.2% with AQ; P < 0.02 for all pairwise comparisons). The risk of recrudescence was lower with AQ + SP (2.1%) compared with SP (6.1%, P = 0.02) and AQ (8.1%, P = 0.001). Risks of new infection were lower with AQ + SP (2.1%) and SP (2.4%) compared with AQ (9.1%, P < 0.001 for both comparisons). No serious adverse events were seen. AQ + SP appears to offer a highly effective, inexpensive, and available therapy for the treatment of uncomplicated malaria in Burkina Faso.

Received April 20, 2005. Accepted for publication June 6, 2005.

Acknowledgments: The authors thank the clinical study teams in the dispensaries of Colsama (Minata Yampa, Christine Ouaro Sylvain Zoundi), Sarlafao (Georgette Dabire, Gneme Moumouni), and Ouezzin-Ville (Yolande Sanou, Korotoumou Sontie, Aissiata Boly) and the laboratory technicians (Patrice Hien, Adama Sankara, Daouda Traore, San Coulibaly, Mahamoudou Minoungou). We also thank Assobga Franck Godefroy, Harouna Zigani, and Halidou Tinto for assistance with data entry and Heidi Hopkins for assistance in protocol preparation.

Financial support: This work was supported by grant D43 TW01506 from the Fogarty International Center of the National Institutes of Health.

^* Address correspondence to Philip J. Rosenthal, Box 0811, University of California, San Francisco, CA 94143. E-mail: rosnthl{at}itsa.ucsf.edu

Authors’ addresses: Issaka Zongo, Noel Rouamba, Moise Lankoande, and Jean-Bosco Ouedraogo, Institut de Recherche en Sciences de la Santé, Bobo-Dioulasso, Burkina Faso. Grant Dorsey, Christian Dokomajilar, and Philip J. Rosenthal, Box 0811, University of California, San Francisco, CA 94143.

Reprint requests: Philip J. Rosenthal, Box 0811, University of California, San Francisco, CA 94143, Telephone: 1-415-206-8845, Fax: 1-415-648-8425, E-mail: rosnthl{at}itsa.ucsf.edu.

This article has been cited by other articles:

				B. Greenhouse, C. Dokomajilar, A. Hubbard, P. J. Rosenthal, and G. Dorsey Impact of Transmission Intensity on the Accuracy of Genotyping To Distinguish Recrudescence from New Infection in Antimalarial Clinical Trials Antimicrob. Agents Chemother., September 1, 2007; 51(9): 3096 - 3103. [Abstract] [Full Text] [PDF]

				A. Sowunmi, G. O. Gbotosho, C. T. Happi, A. A. Adedeji, F. A. Fehintola, O. A. Folarin, E. Tambo, and B. A. Fateye Therapeutic Efficacy and Effects of Artemether-Lumefantrine and Amodiaquine-Sulfalene-Pyrimethamine on Gametocyte Carriage in Children with Uncomplicated Plasmodium falciparum Malaria in Southwestern Nigeria Am J Trop Med Hyg, August 1, 2007; 77(2): 235 - 241. [Abstract] [Full Text] [PDF]

				B. GREENHOUSE, A. MYRICK, C. DOKOMAJILAR, J. M. WOO, E. J. CARLSON, P. J. ROSENTHAL, and G. DORSEY VALIDATION OF MICROSATELLITE MARKERS FOR USE IN GENOTYPING POLYCLONAL PLASMODIUM FALCIPARUM INFECTIONS Am J Trop Med Hyg, November 1, 2006; 75(5): 836 - 842. [Abstract] [Full Text] [PDF]

				C. DOKOMAJILAR, Z. M. LANKOANDE, G. DORSEY, I. ZONGO, J.-B. OUEDRAOGO, and P. J. ROSENTHAL Roles of specific Plasmodium falciparum mutations in resistance to amodiaquine and sulfadoxine-pyrimethamine in burkina faso. Am J Trop Med Hyg, July 1, 2006; 75(1): 162 - 165. [Abstract] [Full Text] [PDF]

				S. R. MESHNICK and A. P. ALKER AMODIAQUINE AND COMBINATION CHEMOTHERAPY FOR MALARIA Am J Trop Med Hyg, November 1, 2005; 73(5): 821 - 823. [Full Text] [PDF]