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Am. J. Trop. Med. Hyg., 73(4), 2005, pp. 710-712
Copyright © 2005 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT


INHIBITORY EFFECT OF LACTOFERRIN ON IN VITRO GROWTH OF BABESIA CABALLI

HIROMI IKADAI*, TETSUYA TANAKA, NONA SHIBAHARA, HIROKO TANAKA, AYA MATSUU, NOBORU KUDO, KEI-ICHI SHIMAZAKI, IKUO IGARASHI, AND TAKASHI OYAMADA
Department of Veterinary Parasitology, and Department of Small Animal Medicine, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori, Japan; Dairy Science Laboratory, Graduate School of Agriculture, Hokkaido University, Sapporo, Hokkaido, Japan; National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan

 

ABSTRACT

Lactoferrin (LF) is an important biologic molecule with many functions, one of which is antimicrobial defense. We evaluated the growth-inhibiting effects of four types of LF (native LF, Fe+3-bound [holo] LF, Fe+3-free [apo] LF, and LF hydrolyzate) on the in vitro growth of Babesia caballi and B. equi. The growth of B. caballi was significantly suppressed in media containing apo LF, but was not inhibited in media containing native LF, holo LF, or LF hydrolyzate. The growth of B. equi was not inhibited by media containing native LF, holo LF, or apo LF. These data indicate that apo LF had the strongest inhibitory effect on B. caballi. This may have been caused by inactivation or inhibition of a growth factor in the culture medium.

Received September 15, 2004. Accepted for publication January 10, 2005.

Financial support: This study was supported by a Grant-in-Aid for Young Scientists from the Ministry of Education, Culture, Sports, Science and Technology of Japan, a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science, and the Kitasato University Research for Young Scientists.

* Address correspondence to Hiromi Ikadai, Department of Veterinary Parasitology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori 034-8628, Japan. E-mail: ikadai{at}vmas.kitasato-u.ac.jp

Authors’ addresses: Hiromi Ikadai, Nona Shibahara, Hiroko Tanaka, Noboru Kudo, and Takashi Oyamada, Department of Veterinary Parasitology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori 034-8628, Japan. Tetsuya Tanaka and Kei-ichi Shimazaki, Dairy Science Laboratory, Graduate School of Agriculture, Hokkaido University, Sapporo, Hokkaido 060-8589, Japan. Aya Matsuu, Department of Small Animal Medicine, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori 034-8628, Japan. Ikuo Igarashi, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan.

Reprints requests: Hiromi Ikadai, Department of Veterinary Parasitology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori 034-8628, Japan, Telephone: 81-176-23-4371, Fax: 81-176-25-0165, E-mail: ikadai{at}vmas.kitasato-u.ac.jp




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 Am J Trop Med HygHome page
H. IKADAI, M. SASAKI, H. ISHIDA, A. MATSUU, I. IGARASHI, K. FUJISAKI, and T. OYAMADA
MOLECULAR EVIDENCE OF BABESIA EQUI TRANSMISSION IN HAEMAPHYSALIS LONGICORNIS
Am J Trop Med Hyg, April 1, 2007; 76(4): 694 - 697.
[Abstract] [Full Text] [PDF]


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Copyright © 2005 by the American Society of Tropical Medicine and Hygiene.