HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via ISI Web of Science (6) Citing Articles via Google Scholar Google Scholar Articles by SCHWARZ, N. G. Articles by GROBUSCH, M. P. Search for Related Content PubMed PubMed Citation Articles by SCHWARZ, N. G. Articles by GROBUSCH, M. P. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Related Collections Malaria

5-DAY NONOBSERVED ARTESUNATE MONOTHERAPY FOR TREATING UNCOMPLICATED FALCIPARUM MALARIA IN YOUNG GABONESE CHILDREN

Despite different recommendations from WHO and national authorities, artesunate monotherapy is increasingly used for treating African children with malaria. A 5-day course of oral artesunate (first day: 4 mg/kg body weight, observed intake; and 2 mg/kg body weight on the following days with nonobserved drug intake) yielded a PCR-corrected Day 28 cure rate of 90% (45 of 50 patients; CI 78–97%) in Gabonese children aged between 2 and 18 months. Artesunate was well tolerated, and no severe adverse events were reported.

Received March 22, 2005. Accepted for publication May 3, 2005.

Acknowledgments: We are grateful to the children and their parents for participation in our longitudinal study. The authors thank Silvelia Grummes for performing the PCR genotyping and all the staff of the Medical Research Unit, the Pediatric Ward and the Maternity Ward of the Albert Schweitzer Hospital for their excellent cooperation.

^* Address correspondence to Martin P. Grobusch, University of the Witwatersrand, Infectious Diseases Unit, Johannesburg, South Africa. E-mail: grobuschmp{at}pathology.wits.ac.za.

Authors’ addresses: Norbert G. Schwarz, Sunny Oyakhirome, Marc Pötschke, Benjamin Gläser, Handan Altun, and Saadou Issifou, Medical Research Unit, Albert Schweitzer Hospital, B.P. 118, Lambaréné, Gabon, Telephone: +241581099. Peter Klein Klouwenberg, Ayola A. Adegnika, Jürgen F. J. Kun, Peter G. Kremsner, and Martin P. Grobusch, Institute of Tropical Medicine, Department of Parasitology, Eberhard Karls University, Wilhelmstr. 27, D-72074 Tübingen, Germany, Telephone: +49 7071 298 0234; Fax +49 7071 29 4684.

Reprint requests: Martin P. Grobusch, University of the Witwatersrand, Infectious Diseases Unit, Johannesburg, South Africa, Telephone: +2711 489 8537; Fax: +2711 489 8530, E-mail: grobuschmp{at}pathology.wits.ac.za.