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Am. J. Trop. Med. Hyg., 73(4), 2005, pp. 667-668
Copyright © 2005 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT


ABNORMAL LIVER FUNCTION IN SCRUB TYPHUS

MING-LUEN HU, JIEN-WEI LIU, KENG-LIANG WU, SHENG-NAN LU, SHUE-SHIAN CHIOU, CHUNG-HUANG KUO, SENG-KEE CHUAH, JING-HOUNG WANG, TSUNG-HUI HU, KING-WAH CHIU, CHUAN-MO LEE*, AND CHI-SIN CHANGCHIEN
Division of Hepatogastroenterology and Infectious Disease, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan

 

ABSTRACT

Scrub typhus is one kind of rickettsial disease and may cause fever, cough, and skin rashes in infected humans. Regarding liver involvement, it was uncommon to be reported in previous medical literature from Western countries. This study observes the relationship between scrub typhus and liver function. From January 1998 to August 2003 in Kaohsiung Chang Gung Memorial Hospital in Taiwan, we observed 30 patients with scrub typhus, and 29 of them had liver function abnormality. In these patients, we found 89.3% with elevated aspartate aminotransferase (AST) levels, 91.7% with elevated alanine aminotransferase (ALT) levels, 84.2% with elevated alkaline phosphatase (ALP) levels, and 38.5% with elevated total bilirubin levels. In our study, there is a close relationship between scrub typhus and impaired liver function tests. Therefore, if patients are found with fever of unknown origin and abnormal liver function, we should take scrub typhus into consideration.

Received February 2, 2005. Accepted for publication April 29, 2005.

Financial support: This study was supported by research grants CMRP 8066 from Chang Gung Memorial Hospital.

* Address correspondence to Chuan-Mo Lee, M.D., Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, 123, Ta Pei Road, Niao Sung Hsiang 833, Kaohsiung Hsien, Taiwan, Republic of China. E-mail: chmolee{at}ms15.hinet.net

Authors’ addresses: Ming-Luen Hu, Keng-Liang Wu, Chi-Sin Changchien, Sheng-Nan Lu, Shue-Shian Chiou, Chung-Huang Kuo, Seng-Kee Chuah, Jing-Houng Wang, Tsung-Hui Hu, King-Wah Chiu, and Chuan-Mo Lee, Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, Republic of China. Jien-Wei Liu, Division of Infectious Disease, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, Republic of China.

Reprint requests: Chuan-Mo Lee, M.D., Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, 123, Ta Pei Road, Niao Sung Hsiang 833, Kaohsiung Hsien, Taiwan, Republic of China, Telephone: 886-7-7317123 (ext. 8301), Fax: 886-7-7322402, E-mail: chmolee{at}ms15.hinet.net.




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