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Am. J. Trop. Med. Hyg., 73(3), 2005, pp. 644-648

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PLASMODIUM SIMIUM AND SAIMIRI BOLIVIENSIS AS A MODEL SYSTEM FOR TESTING CANDIDATE VACCINES AGAINST PLASMODIUM VIVAX

WILLIAM E. COLLINS*, JOANN S. SULLIVAN, G. GALE GALLAND, ALLISON WILLIAMS, DOUGLAS NACE, TYRONE WILLIAMS, AND JOHN W. BARNWELL
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U.S. Public Health Service, Department of Health and Human Services, Atlanta, Georgia

Observations on Plasmodium simium infections in Saimiri boliviensis boliviensis monkeys suggest that this host-parasite combination would be a suitable model for the testing of candidate vaccines against Plasmodium vivax. To evaluate the normal course of infections, parasitemia in 52 splenectomized S. boliviensis boliviensis monkeys infected with P. simium were analyzed. The mean maximum parasite count for 31 monkeys after injection with trophozoite-infected erythrocytes was 77,580/µL. Twenty-one monkeys were infected via sporozoites, and prepatent periods ranged from 14 to 24 days with a median of 15 days. The mean maximum parasite count was 29,234/µL. The mean maximum parasite count for monkeys previously infected with Old World P. vivax was 26,337/µL versus 56,362/µL for those previously infected with New World P. vivax, possibly suggesting a closer antigenic relationship between P. simium and the Old World parasites.

Received January 14, 2005. Accepted for publication April 7, 2005.

Financial support: This work was supported in part by an interagency agreement between the United States Agency for International Development, Malaria Vaccine Development Program, and The Centers for Disease Control and Prevention, project no. 936-6001, and the Atlanta Research and Education Foundation of the Veterans Affairs Medical Center of Atlanta.

* Address correspondence to William E. Collins, Centers for Disease Control and Prevention, Mail Stop F-36, 4770 Buford Highway, Chamblee, GA 30341. E-mail: wec1{at}cdc.gov

Authors’ addresses: William E. Collins, JoAnn S. Sullivan, Douglas Nace, and John W. Barnwell, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Mail Stop F-36, 4770 Buford Highway, Chamblee, GA 30341. G. Gale Galland and Allison Williams, Scientific Resources Program, Centers for Disease Control and Prevention, Atlanta, GA 30333. Tyrone Williams, Atlanta Research and Education Foundation, Atlanta, GA 30033.

Reprint requests: William E. Collins, Centers for Disease Control and Prevention, Mail Stop F-36, 4770 Buford Highway, Chamblee, GA 30341. E-mail: wec1{at}cdc.gov






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