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Am. J. Trop. Med. Hyg., 73(2), 2005, pp. 435-440
Copyright © 2005 by The American Society of Tropical Medicine and Hygiene

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COMPARISON OF CLINICAL FEATURES AND HEMATOLOGIC ABNORMALITIES BETWEEN DENGUE FEVER AND DENGUE HEMORRHAGIC FEVER AMONG CHILDREN IN THE PHILIPPINES

CELIA C. CARLOS, KAZUNORI OISHI*, MARIA T. D. D. CINCO, CYNTHIA A. MAPUA, SHINGO INOUE, DEU JOHN M. CRUZ, MARY ANN M. PANCHO, CAROL Z. TANIG, RONALD R. MATIAS, KOUICHI MORITA, FILIPINAS F. NATIVIDAD, AKIRA IGARASHI, AND TSUYOSHI NAGATAKE
Department of Pediatrics, and Research and Biotechnology Division, St. Luke’s Medical Center, Quezon City, The Philippines; Institute of Biology, University of the Philippines Diliman, Quezon City, The Philippines; Department of Internal Medicine and Virology, Institute of Tropical Medicine Nagasaki University, Nagasaki, Japan

To demonstrate the differences of clinical features and hematologic abnormalities between dengue fever (DF) and dengue hemorrhagic fever (DHF), 359 pediatric patients admitted St. Luke’s Medical Center in Quezon City, between 1999 and 2001 in Metro Manila, and adjoining provinces the Philippines, with a laboratory-confirmed dengue virus infection were evaluated. One third of the patients had DHF, and most of these patients were without shock. Restlessness, epistaxis, and abdominal pain were more associated with DHF. The platelet count was significantly lower in the DHF group than in the DF group before and after defervescence. In the DHF patients, the hematocrit was significantly increased before defervescence, and decreased the day after due to administration of intravenous fluid. Coagulation abnormalities associated with most DHF patients were thrombocytopenia and an increased fibrinolysis, but not disseminated intravascular coagulation. We present recent data on readily obtained clinical and laboratory data that can be used for early diagnosis and consequently earlier appropriate treatment of dengue virus infections.

Received May 30, 2004. Accepted for publication April 13, 2005.

Acknowledgments: We are grateful to Dr. Felicitas S. Aguila, the former Chairman, and the medical staff of Department of Pediatrics, St. Luke’s Medical Center for enrolling their patients in this study, and the technical staff of Research and Biotechnology Division, St. Luke’s Medical Center for the processing of specimens. We also thank Shoko Honda and Mariko Saito for their assistance in the data analysis.

Financial support: This study was supported by a Grant-in-Aid for Scientific Research (B: 14406019) from the Ministry of Education, Science and Culture, Japan and from the St. Luke’s Medical Center (Project no. 18-011).

* Address correspondence to Dr. Kazunori Oishi, Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan. E-mail: oishi-k{at}net.nagasaki-u.ac.jp

Authors’ addresses: Celia C. Carlos and Maria T.D.D. Cinco, Department of Pediatrics, St. Luke’s Medical Center, 279 E. Rodriguez Sr. Boulevard, Cathedral Heights, Quezon City 1102, the Philippines, Telephone: 632-809-9763, Fax: 632-809-9763, E-mail: ccarlos{at}ritm.gov.ph. Kazunori Oishi, Kouichi Morita, Akira Igarashi, and Tsuyoshi Nagatake, Department of Internal Medicine and Virology, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan, Telephone: 81-95-849-7842, Fax: 81-95-849-7843, E-mail: oishi-k{at}net.nagasaki-u.ac.jp. Cynthia A. Mapua, Deu John M. Cruz, Mary Ann M. Pancho, Carol Z. Tanig, and Filipinas F. Natividad, Research and Biotechnology Division, St. Luke’s Medical Center, 279 E. Rodriguez Sr. Boulevard, Cathedral Heights, Quezon City, 1102, the Philippines. Shingo Inoue, Research and Biotechnology Division, St. Luke’s Medical Center, 279 E. Rod-riguez Sr. Boulevard, Cathedral Heights, Quezon City, 1102, The Philippines and Department of Virology, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan. Ronald R. Matias, Research and Biotechnology Division, St. Luke’s Medical Center, 279 E. Rodriguez Sr. Boulevard, Cathedral Heights, Quezon City, 1102, the Philippines and Institute of Biology, University of the Philippines Diliman, Quezon City, the Philippines.




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M.-C. KUO, J.-M. CHANG, P.-L. LU, Y.-W. CHIU, H.-C. CHEN, and S.-J. HWANG
DIFFICULTY IN DIAGNOSIS AND TREATMENT OF DENGUE HEMORRHAGIC FEVER IN PATIENTS WITH CHRONIC RENAL FAILURE: REPORT OF THREE CASES OF MORTALITY
Am J Trop Med Hyg, April 1, 2007; 76(4): 752 - 756.
[Abstract] [Full Text] [PDF]


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Copyright © 2005 by the American Society of Tropical Medicine and Hygiene.