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Am. J. Trop. Med. Hyg., 73(1), 2005, pp. 92-94
Copyright © 2005 by The American Society of Tropical Medicine and Hygiene

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Right arrow Acanthamoeba/Naegleria

ACANTHAMOEBA INFECTION AS A CAUSE OF SEVERE KERATITIS IN A SOFT CONTACT LENS WEARER IN JAMAICA

ZOE WYNTER-ALLISON, JACOB LORENZO MORALES, DONOVAN CALDER, KRAIG RADLEIN, ANTONIO ORTEGA-RIVAS, AND JOHN F. LINDO*
Division of Ophthalmology and Department of Microbiology, The University of the West Indies, Kingston, Jamaica; Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, La Laguna, Tenerife, Canary Islands, Spain

We report the case of a 29-year-old Jamaican patient who presented with severe pain, redness, and swelling of both eyes. She was a regular soft contact lens wearer who did not maintain standard lens care. She was treated for a possible microbial/viral keratitis using topical ciprofloxacin drops, topical acyclovir ointment, and topical atropine drops. The response was inadequate, and scrapings from her cornea, contact lens cases, and both lenses revealed Acanthamoeba on microscopy, which was shown to be Acanthamoeba polyphaga using polymerase chain reaction. She was treated using chlorhexidine 0.02% hourly, ciprofloxacin every 4 hours, and atropine 1% every 12 hours, along with oral ketoconazole 200 mg twice daily with a dramatic response. However, she subsequently suffered slow corneal epithelial regrowth with severe scarring, vascularization, and cortical lens opacification and was referred for penetrating keratoplasty and cataract surgery. This is the first case of severe keratitis caused by Acanthamoeba to be reported from Jamaica and demonstrates that this emerging pathogen can be a cause of severe keratitis in the tropics.

Received September 2, 2004. Accepted for publication January 26, 2005.

Acknowledgments: The American Committee on Clinical Tropical Medicine and Travelers’ Health (ACCTMTH) assisted with publication expenses.

* Address correspondence to John F. Lindo, Department of Microbiology, University of the West Indies, Kingston, Jamaica. E-mail: john.lindo{at}uwimona.edu.jm

Authors’ addresses: Zoe Wynter-Allison, Donovan Calder, Kraig Radlein, and John F. Lindo, University of the West Indies, Kingston, Jamaica. Jacob Lorenzo Morales and Antonio Ortega-Rivas, University of La Laguna, La Laguna, Tenerife, Canary Islands, Spain.






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Copyright © 2005 by the American Society of Tropical Medicine and Hygiene.