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Am. J. Trop. Med. Hyg., 73(1), 2005, pp. 188-190
Copyright © 2005 by The American Society of Tropical Medicine and Hygiene

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OCCULT PLASMODIUM VIVAX INFECTION DIAGNOSED BY A POLYMERASE CHAIN REACTION–BASED DETECTION SYSTEM: A CASE REPORT

DAVID B. BLOSSOM*, CHARLES H. KING, AND KEITH B. ARMITAGE
Division of Infectious Diseases, University Hospitals of Cleveland, Cleveland, Ohio; Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio

After a trip to Zambia, a previously healthy adult traveler presented with a prolonged illness characterized by low-grade fevers and fatigue. Although malaria smears and antibody tests results for Plasmodium species were negative, a diagnosis of malaria was ultimately determined by polymerase chain reaction (PCR) amplification and species-specific nucleic acid hybridization techniques. The patient was successfully treated and cured. Clinical use of PCR technology may facilitate the identification of cases of smear-negative malaria, which up to the present time, have been difficult to diagnose.

Received September 10, 2004. Accepted for publication February 8, 2005.

Acknowledgments: We thank Rajeev K. Mehlotra, Peter A. Zimmerman, and James W. Kazura for their assistance with the PCR-based detection system. The American Committee on Clinical Tropical Medicine and Travelers’ Health (ACCTMTH) assisted with publication expenses.

* Address correspondence to Dr. David B. Blossom, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106-5083. E-mail: david_blossom{at}hotmail.com

Authors’ addresses: David B. Blossom and Keith B. Armitage, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106-5083, Telephone: 216-844-1988, Fax: 216-844-1632, E-mails: david_blossom{at}hotmail.com and kba{at}po.cwru.edu. Charles H. King, Center for Global Health and Diseases, Case Western Reserve University School of Medicine, 2103 Cornell Road, Cleveland, OH 44106-7286, Telephone: 216-368-3667, E-mail: chk{at}po.cwru.edu.

Reprint requests: David B. Blossom, University Hospitals of Cleve-land, 11100 Euclid Avenue, Cleveland, Ohio 44106-5083.






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Copyright © 2005 by the American Society of Tropical Medicine and Hygiene.