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Am. J. Trop. Med. Hyg., 73(1), 2005, pp. 171-173
Copyright © 2005 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT


USEFULNESS OF THE PLASMODIUM FALCIPARUM CHLOROQUINE RESISTANCE TRANSPORTER T76 GENOTYPE FAILURE INDEX FOR THE ESTIMATION OF IN VIVO CHLOROQUINE RESISTANCE IN BURKINA FASO

HALIDOU TINTO, BOROMA SANOU, JEAN-CLAUDE DUJARDIN, JEAN BOSCO OUÉDRAOGO, CHANTAL VAN OVERMEIR, ANNETTE ERHART, ERIC VAN MARCK, TINGA ROBERT GUIGUEMDÉ, AND UMBERTO D’ALESSANDRO*
Centre Muraz/Institut de Recherche en Sciences de la Santé, Bobo Dioulasso, Burkina Faso; Faculty of Medicine, University of Antwerp, Antwerp, Belgium; Prince Leopold Institute of Tropical Medicine, Antwerp, Belgium

 

ABSTRACT

The prevalence of chloroquine (CQ) treatment failure and the genotype failure index was determined in four sentinel sites in Burkina Faso. In three sites, the genotype failure index varied between 1.7 and 3, a result confirming the relationship between the Plasmodium falciparum CQ resistance transporter (Pfcrt) T76 mutation and CQ resistance. In the remaining site, the genotype failure index was unusually low, 1.1, which was significantly different than that in the other sites (P < 0.00001). These findings are discussed. Often but not always, the prevalence of CQ resistance can be correctly estimated by the Pfcrt T76 genotype failure index.

Received July 12, 2004. Accepted for publication December 20, 2004.

Acknowledgments: We thank the parents of the children included in this study for their participation. We also thank the health staff of the health centers where the study was conducted for their collaboration.

Financial support: We thank the French Co-operation for its support of the field study and the Belgium Co-operation for support of the laboratory work through a training grant to Halidou Tinto. This work was also partially support by Société de Pathologie Exotique through a prize awarded to Halidou Tinto.

* Address correspondence to Umberto D’Alessandro, Institute of Tropical Medicine, Nationalestraat 155, Antwerp B-2000, Belgium. E-mail: udalessandro{at}itg.be

Authors’ addresses: Halidou Tinto, Boroma Sanou, Jean Bosco Ouédraogo, and Tinga Robert Guiguemdé, Centre Muraz/Institut de Recherche en Sciences de la Santé, BP 153 Bobo Dioulasso, Burkina Faso, Telephone: 226-20-97-01-02; Fax: 226-20-97-28-24, E-mail: tintoh{at}hotmail.com. Jean-Claude Dujardin, Chantal van Overmeir, Annette Erhart, and Umberto D’Alessandro, Institute of Tropical Medicine, Nationalestraat 155, Antwerp B-2000, Belgium, Telephone: 32-3-247-6354, Fax: 32-3-247-6362, E-mail: udalessandro{at}itg.be. Eric van Marck, Faculty of Medicine, University of Antwerp, Universiteitsplein 1 B-2610, Antwerp, Belgium, Telephone: 32-3-820-2540, Fax: 32-3-820-2501, E-mail: Eric.Van.Marck{at}uza.be.

Reprint requests: Umberto D’Alessandro, Institute of Tropical Medicine, Nationalestraat 155, Antwerp B-2000, Belgium.




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