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Am. J. Trop. Med. Hyg., 73(1), 2005, pp. 122-124
Copyright © 2005 by The American Society of Tropical Medicine and Hygiene

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Right arrow Strongyloidiasis

SUBCUTANEOUS IVERMECTIN AS A SAFE SALVAGE THERAPY IN STRONGYLOIDES STERCORALIS HYPERINFECTION SYNDROME: A CASE REPORT

JEROME PACANOWSKI, MARIE DOS SANTOS, ANTOINE ROUX, CHRISTINE LE MAIGNAN, JACQUES GUILLOT, VERONIQUE LAVARDE, AND MURIEL CORNET*
Départements de Microbiologie, Soins Intensifs de Pneumologie, et d’Oncologie Médicale, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, Pairs, France; Université Paris V, Paris, France; Département de Parasitologie-Mycologie, Ecole Nationale Vétérinaire d’Alfort, Maisons-Alfort, France

Strongyloides stercoralis hyperinfection syndrome due to the acceleration of the autoinfective cycle of the nematode is a life-threatening form of the infection occurring in immunocompromised hosts. Intestinal ileus, which is commonly encountered in this form, may reduce the bioavailability and thus the efficacy of oral anthelminthic drugs used in the treatment of the S. stercoralis hyperinfection syndrome. We report the efficacy and safety of subcutaneous administration of ivermectin in a patient infected with human T cell lymphotropic virus type I with S. stercoralis hyperinfection syndrome who was unresponsive to an oral combination of ivermectin and albendazole.


Received September 28, 2004. Accepted for publication January 19, 2005.

* Address correspondence to Muriel Cornet, Laboratoire de Microbiologe, Hôtel-Dieu, 1, Place du Parvis Notre-Dame, 75181, Paris Cedex 04, France. E-mail: mucornet{at}aol.com

Authors’ addresses: Jerome Pacanowski, Service de Maladies Infectieuses, Hôpital Saint-Antoine, 184 Rue du Faubourg Saint-Antoine, 75012 Paris, France. Marie Dos Santos and Veronique Lavarde, Laboratoire de Microbiologie, Hôpital Européen Georges Pompidou, 20 Rue Leblanc, 75015 Paris, France. Antoine Roux, Service de Pneumologie, Hôpital Européen Georges Pompidou, 20 Rue Leblanc, 75015 Paris, France. Christine Le Maignan, Service d’Oncologie Médicale, Hôpital Européen Georges Pompidou, 20 Rue Leblanc, 75015 Paris, France. Jacques Guillot, Département de Parasitologie-Mycologie, Ecole Vétérinaire d’Alfort, 7 Avenue du Général de Gaulle, 94700 Maisons-Alfort, France. Muriel Cornet, Laboratoire de Microbiologie, Hôtel-Dieu, 1, Place du Parvis Notre-Dame, 75181, Paris Cedex 04, France, Telephone: 33-1-42-34-82-73, Fax: 33-1-42-34-87-19, E-mail: mucornet{at}aol.com.




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