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Am. J. Trop. Med. Hyg., 72(6), 2005, pp. 851-854
Copyright © 2005 by The American Society of Tropical Medicine and Hygiene

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SURVEILLANCE FOR ANTIMICROBIAL RESISTANCE PROFILES AMONG SHIGELLA SPECIES ISOLATED FROM A SEMIRURAL COMMUNITY IN THE NORTHERN ADMINISTRATIVE AREA OF SANTIAGO, CHILE

NOELIA FULLÁ, VALERIA PRADO, CLAUDIA DURÁN, ROSANNA LAGOS, AND MYRON M. LEVINE
Programa de Microbiología, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile; Centro para Vacunas en Desarrollo, Santiago, Chile; Center for Vaccine Development, University of Maryland, School of Medicine, Baltimore, Maryland

Variations in antibiotic resistance patterns were studied among 178 Shigella strains isolated from 1997 to 2001 in children less than five years of age with acute diarrhea from Colina, a semi-rural community in Santiago, Chile. The minimal inhibitory concentration of several commonly used antibiotics was determined by the agar dilution method. Shigella strains showed high rates of resistance to ampicillin (82%), cotrimoxazole (65%), tetracycline (53%), and chloramphenicol (49%). Furthermore, 51% of the strains showed resistance patterns to multiple antibiotics. Only 9% of the strains were resistant to amoxicillin-clavulanic acid and no resistance was observed to ciprofloxacin, nalidixic acid, or cefotaxime. Continuous monitoring of resistance patterns in Shigella is essential for establishing and updating guidelines for antibiotic treatment in shigellosis.

Received April 30, 2004. Accepted for publication October 12, 2004.

Acknowledgments: We are indebted to Peter Feng for his careful review of the manuscript and editorial suggestions.

Financial support: This study was supported by a research grant from Bill and Melinda Gates Foundation to the Center for Vaccine Development, University of Maryland.

Authors’ addresses: Noelia Fullá, Valeria Prado, and Claudia Durán, Programa de Microbiología, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Correo 7, Clasificador 7, Santiago, Chile, Telephone: 56-2-678 6641, Fax: 56-2-735 5855, E-mails: promicro{at}med.uchile.cl and vprado{at}med.uchile.cl. Rosanna Lagos, Centro para Vacunas en Desarrollo, Santiago, Chile, Telephone: 56-2-737 5022, Fax: 56-2-777 5766, E-mail: rlagos{at}adsl.tie.cl. Myron M. Levine, Center for Vaccine Development, University of Maryland, School of Medicine, Baltimore, MD 21201, Telephone: 410-706-7588, Fax: 410-706-6205, E-mail: Mlevine{at}medicine.umaryland.edu.






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