AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 72(6), 2005, pp. 800-804
Copyright © 2005 by The American Society of Tropical Medicine and Hygiene

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CLINICAL SURVEY OF HANTAVIRUS IN SOUTHERN BRAZIL AND THE DEVELOPMENT OF SPECIFIC MOLECULAR DIAGNOSIS TOOLS

SONIA M. RABONI, GISÉLIA RUBIO, LUANA DE BORBA, AURÉLIO ZEFERINO, IRENE SKRABA, SAMUEL GOLDENBERG, AND CLAUDIA N. DUARTE DOS SANTOS
Instituto de Biologia Molecular do Paraná/FIOCRUZ, Curitiba, Brazil; Secretaria Estadual de Saúde do Paraná, Curitiba, Brazil; Laboratório Central do Estado do Paraná, Curitiba, Brazil

Hantavirus pulmonary syndrome (HPS) is an emerging disease caused by an increasing number of distinct hantavirus serotypes found worldwide. It is also a very severe immune disease. It progresses quickly and is associated with a high mortality rate. At the prodrome phase, hantavirosis symptoms can resemble those of other infectious diseases such as leptospirosis and influenza. Thus, prognosis could be improved by developing a rapid and sensitive diagnostic test for hantavirus infection, and by improving knowledge about clinical aspects of this disease. This study describes clinical features and laboratory parameters throughout the course of HPS in 98 patients. We report the seasonality and regional distribution of this disease in Paraná State, Brazil during the last seven years. In addition, we evaluated a specific molecular diagnostic test based on a nested reverse transcriptase-polymerase chain reaction for the detection of hantaviruses circulating in Brazil.

Received June 3, 2004. Accepted for publication August 12, 2004.

Acknowledgments: We thank Christian Probst, Hadriano Lacerda, and Juliano Bordignon for helpful discussions and comments on the manuscript.

Financial support: This work was supported by FIOCRUZ and Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq).

Authors address: Sonia M. Raboni, Luana de Borba, Aurélio Zeferino, Samuel Goldenberg, and Claudia N. Duarte dos Santos, Instituto de Biologia Molecular do Paraná, Rua Professor Algacyr Munhoz Mader, 3775 81350-010 Curitiba, PR, Brazil, Telephone: 55-41-316-3230, Fax: 55-41-316-3267, E-mails: sraboni{at}onda.com.br, luturtle{at}onda.com.br, aurelio{at}tecpar.br, sgoldenb{at}tecpar.br, and clsantos{at}tecpar.br. Gisélia Rubio, Secretaria Estadual de Saúde do Paraná, Curitiba, PR, Brazil, E-mail: giselia{at}pr.gov.br. Irene Skrabas, Laboratório Central do Estado do Paraná, Curitiba PR, Brazil, E-mail: ireneskrabas{at}bol.com.br.






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