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Am. J. Trop. Med. Hyg., 72(6), 2005, pp. 783-785
Copyright © 2005 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT


TH2 IMMUNE RESPONSE IN PATIENTS WITH DENGUE DURING DEFERVESCENCE: PRELIMINARY EVIDENCE

ULAGANATHAN MABALIRAJAN, TAMILARASU KADHIRAVAN, S. K. SHARMA, AMIT BANGA, AND BALARAM GHOSH
Molecular Immunology and Immunogenetics Laboratory, Institute of Genomics and Integrative Biology, Delhi, India; Department of Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India

 

ABSTRACT

A shift from a TH1 to a TH2 immune response has been observed in vitro during dengue virus infection. Estimation of plasma IgE level (n = 28), CD4:CD8 lymphocyte ratio, and the intracellular interferon-{gamma} (IFN-{gamma}):interleukin-4 (IL-4) ratio (n = 9) was conducted in patients with various severities of dengue around the time of defervescence. The CD4:CD8 lymphocyte ratio was significantly lower (median = 0.45, interquartile range [IQR] = 0.4–0.47 versus 1.3, 1.0–1.9; P = 0.001), and IgE levels were significantly higher (mean = 300.4, SD = 252.5 versus 143.7, 117.9 IU/mL; P = 0.004) in patients than in healthy controls. The intracellular IFN-{gamma}:IL-4 ratio was significantly lower in patients compared with controls (0.28, 0.13 versus 0.99, 0.4; P = 0.001). These findings suggest that a TH2 immune response occurs in patients with dengue around the time of defervescence.

Received July 26, 2004. Accepted for publication November 19, 2004.

Acknowledgments: The American Society of Tropical Medicine and Hygiene (ASTMH) assisted with publication expenses.

Authors’ addresses: Ulaganathan Mabalirajan and Balaram Ghosh, Molecular Immunology and Immunogenetics Laboratory, Institute of Genomics and Integrative Biology, Mall Road, Delhi-110007, India. Tamilarasu Kadhiravan, S. K. Sharma, and Amit Banga, Department of Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029, India, Telephone: 91-11-2659-4415, Fax: 91-11-2658-9898, E-mail: sksharma{at}aiims.ac.in.




This article has been cited by other articles:


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B. E. E. Martina, P. Koraka, and A. D. M. E. Osterhaus
Dengue Virus Pathogenesis: an Integrated View
Clin. Microbiol. Rev., October 1, 2009; 22(4): 564 - 581.
[Abstract] [Full Text] [PDF]


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