HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (8) Citing Articles via Google Scholar Google Scholar Articles by PENNETIER, C. Articles by HOUGARD, J.-M. Search for Related Content PubMed PubMed Citation Articles by PENNETIER, C. Articles by HOUGARD, J.-M. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB DEET PROPOXUR Related Collections Mosquitoes

COMBINATION OF A NON-PYRETHROID INSECTICIDE AND A REPELLENT: A NEW APPROACH FOR CONTROLLING KNOCKDOWN-RESISTANT MOSQUITOES

Although pyrethroid-treated materials are a promising tool for the prevention and the control of dengue in the tropics, the development of pyrethroid resistance in the main mosquito vector (Aedes aegypti) may negate their use for personal and/or community protection. In that context, the efficacy of a mixture of a repellent (N,N-diethyl toluamide [DEET]) and a non-pyrethroid insecticide (propoxur) was investigated under laboratory conditions against both pyrethroid-susceptible and pyrethroid-resistant mosquitoes with the knockdown resistance (kdr) mutation. The results showed that a combination of propoxur and DEET induced a knockdown effect and mortality as high as deltamethrin (a standard pyrethroid) against the susceptible strain, and significantly higher efficacy against the pyrethroid-resistant strain. This could be explained mainly by the existence of a strong synergistic interaction between DEET and propoxur in mosquitoes. This study constitutes a first step towards an alternative strategy for improving mosquito control in areas with pyrethroid resistance.

Received September 24, 2004. Accepted for publication December 13, 2004.

Acknowledgments: We are very grateful to Raphael N’Guessan (London School of Hygiene and Tropical Medicine) for helpful comments and discussions. We also thank Bayer (Leverkusen, Germany), Agrevo (Berkhamsted, United Kingdom), and Sigma-Aldrich (Saint Quentin Fallavier, France) for providing the technical grades of propoxur, deltamethrin, and DEET.

Authors’ addresses: Cédric Pennetier and Vincent Corbel, Laboratoire de Lutte contre les Insectes Nuisibles, Institut de Recherche pour le Développement, 911 Avenue Agropolis, BP 64501, 34394 Montpellier cedex 5, France, Telephone: 33-467-04-19-24, Fax: 33-467-54-20-44, E-mails: cedric.pennetier{at}ird.fr and corbel{at}mpl.ird.fr. Jean-Marc Hougard, Centre Institut de Recherche pour le Développement du Benin, 01 BP 4414 RP, Cotonou, Benin, Telephone: 229-30-03-54, Fax: 229-30-88-60, E-mail: hougard{at}ird.fr.

This article has been cited by other articles:

				B. Fei and J. H. Xin N, N-diethyl-m-toluamide-Containing Microcapsules for Bio-Cloth Finishing Am J Trop Med Hyg, July 1, 2007; 77(1): 52 - 57. [Abstract] [Full Text] [PDF]

				J. I. Moss IN REPLY Am J Trop Med Hyg, April 1, 2006; 74(4): 520 - 520. [Full Text] [PDF]

				C. Pennetier, J.-M. Hougard, and V. Corbel IN REPLY Am J Trop Med Hyg, April 1, 2006; 74(4): 520 - 520. [Full Text] [PDF]