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Am. J. Trop. Med. Hyg., 72(6), 2005, pp. 708-713
Copyright © 2005 by The American Society of Tropical Medicine and Hygiene

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ANTIBODY REACTIVITY TO LINEAR EPITOPES OF PLASMODIUM FALCIPARUM CYTOADHERENCE-LINKED ASEXUAL GENE 9 IN ASYMPTOMATIC CHILDREN AND ADULTS FROM PAPUA NEW GUINEA

KATHARINE R. TRENHOLME, CRAIG S. BOUTLIS, RACHEL KUNS, MOSES LAGOG, MOSES J. BOCKARIE, MICHELLE L. GATTON, DAVID J. KEMP, MICHAEL F. GOOD, NICHOLAS M. ANSTEY, AND DONALD L. GARDINER
Division of Infectious Diseases and Immunology, The Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research, Brisbane, Queensland, Australia; International Health Program, Menzies School of Health Research, Casuarina, Darwin, Northern Territory, Australia; Papua New Guinea Institute of Medical Research, Madang, Papua, New Guinea

The cytoadherence-linked asexual gene 9 (clag 9) of Plasmodium falciparum has been implicated in the cytoadherence of infected erythrocytes. To determine the immunogenicity of the clag 9 gene product (CLAG 9 protein) in humans, we measured antibody responses to 11 synthetic CLAG 9 peptides in a group of 177 asymptomatic children and adults subject to intense malaria exposure in Madang, Papua New Guinea. The CLAG 9 peptides were immunogenic in adults and children. Antibody responses to peptides 4 and 10 were high across all age groups and detectable in a majority of children less than five years of age. While CLAG 9 peptides are immunogenic in humans, longitudinal studies will be required to determine the longevity of antibody responses to CLAG 9 and their role in protection from disease.

Received July 26, 2004. Accepted for publication September 14, 2004.

Financial support: This work was supported by Australian National Health and Medical Research Council (NHMRC) grant no. 199608 to David J. Kemp, Katharine R. Trenholme, and Donald L. Gardiner, and by a generous donation from Mark Nicholson, Alice Hill and the Tudor Foundation. Craig S. Boutlis was supported by an NHMRC postgraduate scholarship and Nicholas M. Anstey was supported by an NHMRC Practitioner Fellowship. Michelle L. Gatton was supported by a University of Queensland post-doctoral research fellowship.

Authors’ addresses: Katharine R. Trenholme, Rachel Kuns, Michelle L. Gatton, David J. Kemp, Michael F. Good, and Donald L. Gardiner. Division of Infectious Diseases and Immunology, The Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland, Australia, 4006, Telephone: 61-7-3362-0222, Fax: 61-7-3362-0111. Craig S. Boutlis and Nicholas M. Anstey, Department of Tropical Medicine and International Health, Menzies School of Health Research, PO Box 41096, Casuarina, Darwin, Northern Territory, Australia 0811, Telephone: 61-8-8922-8196, Fax: 61-8-8927-5187. Moses Lagog and Moses J. Bockarie, Papua New Guinea Institute of Medical Research, PO Box 378, Madang, Papua New Guinea, Telephone: 675-852-2909, Fax: 675-852-3289.

Reprint requests: Katharine R. Trenholme, Queensland Institute of Medical Research, 300 Herston Road, Queensland, Australia, 4006, E-mail: kathT{at}qimr.edu.au.






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Copyright © 2005 by the American Society of Tropical Medicine and Hygiene.