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Am. J. Trop. Med. Hyg., 72(4), 2005, pp. 465-467
Copyright © 2005 by The American Society of Tropical Medicine and Hygiene

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ACTIVATION OF CYTOTOXIC LYMPHOCYTES IN PATIENTS WITH SCRUB TYPHUS

MAAIKE DE FOST, WIRONGRONG CHIERAKUL, KRIANGSAK PIMDA, ARJEN M. DONDORP, NICHOLAS J. WHITE, AND TOM VAN DER POLL
Laboratory of Experimental Internal Medicine and Department of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Department of Medicine, Udon Thani General Hospital, Udon Thani, Thailand; Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom

Thai patients with scrub typhus caused by the intracellular pathogen Orientia tsutsugamushi displayed elevated plasma concentrations of granzymes A and B, interferon-{gamma} (IFN)-{gamma}–inducible protein 10, and monokine induced by IFN-{gamma}. These data suggest that activation of cytotoxic lymphocytes is part of the early host response to scrub typhus.

Received August 26, 2004. Accepted for publication October 3, 2004.

Acknowledgments: We are grateful to Naowanit Boonyarueng and all the staff of the Department of Medicine, Udon Thani General Hospital, Udon Thani, Thailand, for help in collecting specimens and clinical data.

Financial support: This study was part of the Wellcome Trust-Mahidol University, Oxford Tropical Medicine Research Program supported by the Wellcome Trust of Great Britain.

Authors’ addresses: Maaike de Fost, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room F4-222, 1105AZ Amsterdam, the Netherlands, Telephone: 31-20-5662171, Fax: 31-20-6977192, E-mail: e-mail m.defost{at}amc.uva.nl. Wirongrong Chierakul, Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok, Thailand, Telephone: 66-2-354-1395, Fax: 66-2-354-9169, E-mail: alwcr{at}diamond.mahidol.ac.th. Kriangsak Pimda, Medical Department, Udon Thani General Hospital, Muang District, Udon Thani, Thailand, Telephone: 66-4-243-8888, Fax: 66-4-234-7733. Arjen M. Dondorp and Nicholas J. White, Wellcome Unit, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok, Thailand, Telephone: 66-2-354-1395, Fax: 66-2-354-9169, E-mails: arjen{at}tropmedres.ac and nickw{at}tropmedres.ac. Tom van der Poll, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, 1105AZ Amsterdam, the Netherlands, Telephone: 31-20-566-5910, Fax: 31-20-697-7192, E-mail: t.vanderpoll{at}amc.uva.nl.






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Copyright © 2005 by the American Society of Tropical Medicine and Hygiene.