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Am. J. Trop. Med. Hyg., 72(4), 2005, pp. 368-369
Copyright © 2005 by The American Society of Tropical Medicine and Hygiene

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HYPERCALCEMIA IN HEPATIC TUBERCULOSIS: A CASE REPORT IN KOREA

EUN SEOK KANG, MI YOUNG DO, SO YOUNG PARK, KYU YEON HUR, CHUL WOO AHN, BONG SOO CHA, SUNG KIL LIM, KYUNG RAE KIM, AND HYUN CHUL LEE
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea

Although primary hyperparathyroidism and malignant diseases account for approximately 90% of the causes of hypercalcemia, they could occur in association with granulomatous diseases such as tuberculosis or sarcoidosis, especially in developing countries. Hepatic tuberculosis is difficult to diagnosis without suspicion in cases with normal findings on chest radiographs. We report a 70-year-old woman who presented with hypercalcemia due to hepatic tuberculosis. The diagnosis was made by a computed tomography scan and laparoscopic evaluation. After treatment with anti-tuberculosis medication, her hypercalcemia resolved. Increased vitamin D synthesis by activated macrophages in the granuloma tissue is the major mechanism of hypercalcemia in tuberculosis.

Received October 6, 2004. Accepted for publication November 23, 2004.

Authors’ addresses: Eun Seok Kang, Mi Young Do, So Young Park, Kyu Yeon Hur, Chul Woo Ahn, Bong Soo Cha, Sung Kil Lim, Kyung Rae Kim, and Hyun Chul Lee, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.

Reprint requests: Hyun Chul Lee, Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchondong Seodaemungu, Seoul 120-752, South Korea, Telephone: 82-2-361-5425, Fax: 82-2-393-6884, E-mail: edgo{at}yumc.yonsei.ac.kr.






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Copyright © 2005 by the American Society of Tropical Medicine and Hygiene.