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Am. J. Trop. Med. Hyg., 72(3), 2005, pp. 320-324
Copyright © 2005 by The American Society of Tropical Medicine and Hygiene

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PERSISTENT SHEDDING OF WEST NILE VIRUS IN URINE OF EXPERIMENTALLY INFECTED HAMSTERS

JESSICA H. TONRY, SHU-YUAN XIAO, MARINA SIIRIN, HONGLI CHEN, AMELIA P. A. TRAVASSOS DA ROSA, AND ROBERT B. TESH
Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas

Adult hamsters that survived experimental West Nile virus (WNV) infection developed persistent viruria. Infectious WNV could be cultured from their urine for up to 52 days. Immunohistochemical examination of kidneys of viruric animals showed foci of WNV antigen in renal tubular epithelial and vascular endothelial cells. These findings are compatible with virus replication and persistent infection of renal epithelial cells. The potential clinical and virologic significance of these findings as well as their possible epidemiologic importance are discussed.

Received August 30, 2004. Accepted for publication September 27, 2004.

Acknowledgments: We thank Hilda Guzman and Mengyi Ye for excellent technical assistance and Dora Salinas for help in preparing the manuscript.

Financial support: This work was supported in part by Centers for Disease Control and Prevention contract U50/CCU620541 and National Institutes of Health contracts NO1-AI25489 and NO1-AI30027.

Authors’ address: Jessica H. Tonry, Shu-Yuan Xiao, Marina Siirin, Hongli Chen, Amelia P. A. Travassos da Rosa, and Robert B. Tesh, Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0609.

Reprint requests: Robert B. Tesh, Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0609, Telephone 409-747-2431, Fax: 409-747-2429, E-mail: rtesh{at}utmb.edu.




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