AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 72(2), 2005, pp. 142-144
Copyright © 2005 by The American Society of Tropical Medicine and Hygiene

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Right arrow Toxoplasmosis

SHORT REPORT: NEONATAL SCREENING PILOT STUDY OF TOXOPLASMA GONDII CONGENITAL INFECTION IN MEXICO

MARCELA VELA-AMIEVA, IRMA CAÑEDO-SOLARES, PEDRO GUTIÉRREZ-CASTRELLÓN, MARTHA PÉREZ-ANDRADE, CLAUDIA GONZÁLEZ-CONTRERAS, JOEL ORTÍZ-CORTÉS, VENANCIO ORTEGA-VELÁZQUEZ, MARIA DE LA LUZ GALVÁN-RAMÍREZ, MATILDE RUIZ-GARCÍA, PATRICA SALTIGERAL-SIMENTEL, JUAN CARLOS ORDAZ-FAVILA, CARMEN SÁNCHEZ, AND DOLORES CORREA
Instituto Nacional de Pediatría, Secretaría de Salud, Mexico City, Mexico; Laboratorio de Enfermedades Tropicales, Centro Universitario de Ciencias de la Salud de la Universidad de Guadalajara, Jalisco, Mexico

 

ABSTRACT

Congenital toxoplasmosis is an obstetric problem in Mexico, but its actual frequency is unknown. Using a network for screening of non-infectious disorders, we performed a pilot study to determine the frequency of IgM antibodies to Toxoplasma gondii in 1,003 infants (53.1% male, mean ± SD age = 18.3 ± 13.0 days, birth weight = 3.116 ± 0.453 kg) in Mexico City from March to April 2003. Blood samples embedded in filter paper were assayed for IgM antibodies using a capture enzyme-linked immunosorbent assay and results were confirmed by Western blot. Two asymptomatic newborns, one of them premature, had IgM and IgG antibodies in a serum sample taken from both the infant and the mother and were clinically followed. Our data suggest a frequency of approximately two cases of congenital T. gondii infection per 1,000 newborns in Mexico City.

Received July 2, 2004. Accepted for publication September 28, 2004.

Authors’ addresses: Marcela Vela-Amieva, Martha Pérez-Andrade, Claudia González-Contreras, Joel Ortíz-Cortés, and Venancio Ortega-Velázquez. Servicio de Genética de la Nutrición, Instituto Nacional de Pediatría, Secretaría de Salud, Av. Insurgentes Sur 3700-C, Colonia Insurgentes Cuicuilco, Mexico City 04530, DF, Mexico, E-mail: amieva{at}servidor.unam.mx. Irma Cañedo-Solares and Dolores Correa, Subdirección de Medicina Experimental, Instituto Nacional de Pediatría, Secretaría de Salud, Av. Insurgentes Sur 3700-C, Colonia Insurgentes Cuicuilco, Mexico City 04530, DF, Mexico, E-mail: mariadol{at}yahoo.com. Pedro Gutiérrez-Castrellón, Departamento de Metodología de la Investigación, Instituto Nacional de Pediatría, Secretaría de Salud, Av. Insurgentes Sur 3700-C, Colonia Insurgentes Cuicuilco, Mexico City 04530, DF, Mexico, E-mail: pedro63{at}prodigy.net.mx. Maria de la Luz Galván-Ramírez. Centro Universitario de Ciencias de la Salud de la Universidad de Guadalajara, Sierra Mojada 950 Edificio N 1er nivel, Colonia Independencia, Guadalajara, 44125, Jalisco, Mexico. Matilde Ruiz-García, Servicio de Neurología, Instituto Nacional de Pediatría, Secretaría de Salud, Av. Insurgentes Sur 3700-C, Colonia Insurgentes Cuicuilco, Mexico City 04530, DF, Mexico. Patrica Saltigeral-Pimentel, Servicio de Infectología, Instituto Nacional de Pediatría, Secretaría de Salud, Av. Insurgentes Sur 3700-C, Colonia Insurgentes Cuicuilco, Mexico City 04530, DF, Mexico. Juan Carlos Ordaz-Favila. Servicio de Oftalmología, Instituto Nacional de Pediatría, Secretaría de Salud, Av. Insurgentes Sur 3700-C, Colonia Insurgentes Cuicuilco, Mexico City 04530, DF, Mexico. Carmen Sánchez, Laboratorio de Seguimiento del Neurodesarrollo, Instituto Nacional de Pediatría, Secretaría de Salud, Av. Insurgentes Sur 3700-C, Colonia Insurgentes Cuicuilco, Mexico City 04530, DF, Mexico, Telephone: 52-55-1084-0900 extensions 1455 or 1458, Fax: 52-55-1084-3883.




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Newborn screening for congenital toxoplasmosis: feasible, but benefits are not established.
Arch. Dis. Child., August 1, 2006; 91(8): 629 - 631.
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