AJTMH ASTMH MEMBERSHIP INFORMATION: astmh@astmh.org
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 71(6), 2004, pp. 828-830
Copyright © 2004 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (3)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by GONZALEZ, A.
Right arrow Articles by CANO, L. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by GONZALEZ, A.
Right arrow Articles by CANO, L. E.
Related Collections
Right arrow Immunology
Right arrow Paracoccidioidomycosis

SHORT REPORT: INHIBITION BY TUMOR NECROSIS FACTOR-{alpha}–ACTIVATED MACROPHAGES OF THE TRANSITION OF PARACOCCIDIOIDES BRASILIENSIS CONIDIA TO YEAST CELLS THROUGH A MECHANISM INDEPENDENT OF NITRIC OXIDE

ANGEL GONZALEZ, BEATRIZ H. ARISTIZÁBAL, ERIKA CARO GÓMEZ, ANGELA RESTREPO, AND LUZ E. CANO
Medical and Experimental Mycology Group, Corporación para Investigaciones Biológicas, Medellín, Colombia; Molecular Microbiology Group, Clinical Laboratory and Bacteriology School, Universidad de Antioquia, Medellín, Colombia

 

ABSTRACT

It is known that peritoneal murine macrophages activated with interferon-{gamma} exert a fungicidal effect against Paracoccidioides brasiliensis conidia by a nitric oxide (NO)-mediated mechanism. This NO-mediated effect can also be induced by other cytokines such as tumor necrosis factor-{alpha} (TNF-{alpha}). The aim of this study was to determine if TNF-{alpha}-activated peritoneal murine macrophages infected with P. brasiliensis were able to show fungistatic/fungicidal effects mediated by NO. The results indicated that although macrophage activation with TNF-{alpha} did not result in NO production, these cells played an important role in inhibiting the conidia from becoming yeast cells. In vivo, the NO-independent inhibitory effect would prove of importance for the establishment of P. brasiliensis in host tissues.

Received May 13, 2004. Accepted for publication July 14, 2004.

Financial support: This work was supported by the Instituto Colombiano para el Desarrollo de la Ciencia y la Tecnología, Francisco José de Caldas, COLCIENCIAS, Santafe de Bogota, Colombia (grants 2213-04-153-97 and 2213-04-1021-98), and by the Corporación para Investigaciones Biológicas (Medellín, Colombia).

Authors’ address: Angel Gonzalez, Beatriz H. Aristizábal, Erika Caro Gómez, Angela Restrepo, and Luz E. Cano. Medical and Experimental Mycology Group, Corporación para Investigaciones Biológicas, Carrera 72 A, No. 78 B 141, AA 73 78, Medellín, Colombia, Telephone: 57-4-441-0855, Fax: 57-4-441-5514, E-mails: agonzalezm{at}cib.org.co, baristizabal{at}cib.org.co, egomez{at}cib.org.co, arestrepo{at}cib.org.co, lcano{at}cib.org.co.




This article has been cited by other articles:


Home page
 J. Leukoc. Biol.Home page
A. Pina, S. Bernardino, and V. L. G. Calich
Alveolar macrophages from susceptible mice are more competent than those of resistant mice to control initial Paracoccidioides brasiliensis infection
J. Leukoc. Biol., May 1, 2008; 83(5): 1088 - 1099.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2004 by the American Society of Tropical Medicine and Hygiene.