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Am. J. Trop. Med. Hyg., 71(6), 2004, pp. 828-830
Copyright © 2004 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT: INHIBITION BY TUMOR NECROSIS FACTOR-{alpha}–ACTIVATED MACROPHAGES OF THE TRANSITION OF PARACOCCIDIOIDES BRASILIENSIS CONIDIA TO YEAST CELLS THROUGH A MECHANISM INDEPENDENT OF NITRIC OXIDE

ANGEL GONZALEZ, BEATRIZ H. ARISTIZÁBAL, ERIKA CARO GÓMEZ, ANGELA RESTREPO, AND LUZ E. CANO
Medical and Experimental Mycology Group, Corporación para Investigaciones Biológicas, Medellín, Colombia; Molecular Microbiology Group, Clinical Laboratory and Bacteriology School, Universidad de Antioquia, Medellín, Colombia

 

ABSTRACT

It is known that peritoneal murine macrophages activated with interferon-{gamma} exert a fungicidal effect against Paracoccidioides brasiliensis conidia by a nitric oxide (NO)-mediated mechanism. This NO-mediated effect can also be induced by other cytokines such as tumor necrosis factor-{alpha} (TNF-{alpha}). The aim of this study was to determine if TNF-{alpha}-activated peritoneal murine macrophages infected with P. brasiliensis were able to show fungistatic/fungicidal effects mediated by NO. The results indicated that although macrophage activation with TNF-{alpha} did not result in NO production, these cells played an important role in inhibiting the conidia from becoming yeast cells. In vivo, the NO-independent inhibitory effect would prove of importance for the establishment of P. brasiliensis in host tissues.

Received May 13, 2004. Accepted for publication July 14, 2004.

Financial support: This work was supported by the Instituto Colombiano para el Desarrollo de la Ciencia y la Tecnología, Francisco José de Caldas, COLCIENCIAS, Santafe de Bogota, Colombia (grants 2213-04-153-97 and 2213-04-1021-98), and by the Corporación para Investigaciones Biológicas (Medellín, Colombia).

Authors’ address: Angel Gonzalez, Beatriz H. Aristizábal, Erika Caro Gómez, Angela Restrepo, and Luz E. Cano. Medical and Experimental Mycology Group, Corporación para Investigaciones Biológicas, Carrera 72 A, No. 78 B 141, AA 73 78, Medellín, Colombia, Telephone: 57-4-441-0855, Fax: 57-4-441-5514, E-mails: agonzalezm{at}cib.org.co, baristizabal{at}cib.org.co, egomez{at}cib.org.co, arestrepo{at}cib.org.co, lcano{at}cib.org.co.




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[Abstract] [Full Text] [PDF]


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Copyright © 2004 by the American Society of Tropical Medicine and Hygiene.