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To determine the age-stratified exposure to hepatitis E virus (HEV) in patients attending a tertiary care hospital in southern India, serum samples from 600 individuals were tested using a commercial HEV IgG enzyme-linked immunosorbent assay. Subjects were composed of blood donors, antenatal women, and pre-operative individuals who were negative for hepatitis B surface antigen and antibody to hepatitis C virus with no evidence of liver disease; 200 each were 1–5 and 6–15 years old and 100 each were 16–40 and 
41 years old. One (0.5%) sample was positive in those 1–5 years old, two (1.0%) in those 6–15 years old, eight (8%) in those 16–40 years old, and 13 (13%) in those 41 years old. The overall seropositivity rate was 4%. However, there was an age-related increase in exposure to HEV that was statistically significant (P < 0.001), with a higher HEV seropositivity in urban individuals.
Received April 30, 2004. Accepted for publication June 16, 2004.
Financial support: This study was partially supported by a Fluid Research Grant (grant number 5000) from the Christian Medical College, Vellore.
Authors’ addresses: Hubert Darius J. Daniel, Department of Clinical Virology, Christian Medical College, Vellore Tamil Nadu, India, Telephone: 91-416-228-2616, Fax: 91-416-223-2035, E-mail: hubertdariusj{at}yahoo.com. Aswin Warier, Department of Clinical Virology, Christian Medical College, Vellore Tamil Nadu, India, Telephone: 91-416-228-2616, Fax: 91-416-223-2035, E-mail: aw21{at}rediffmail.com. Priya Abraham, Department of Clinical Virology, Christian Medical College, Vellore Tamil Nadu, India, Telephone: 91-416-228-2772 or 91-416-228-2616, Fax: 91-416-223-2035, E-mails: priyaabraham{at}cmcvellore.ac.in and apriya_98{at}yahoo.com. Gopalan Sridharan, Department of Clinical Virology, Christian Medical College, Vellore Tamil Nadu, India, Telephone: 91-416-228-2070 or 91-416-228-2312, Fax: 91-416-223-2035, E-mail: g_sridharan{at}yahoo.com.
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