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OXIDATIVE STRESS IN ADULT DENGUE PATIENTS

An association between viral diseases and increased oxidative stress has been suggested. The time course of serum levels of total antioxidant status (TAS), peroxidation potential (PP), glutathione (GSH), lipid peroxidation measured as hydroperoxides, and malondyaldehyde and 4-hydroxyalkenals (MDA + 4-HDA), as well as antioxidant enzymatic activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx), were measured in 22 serologically confirmed dengue patients. Most of the patients had dengue fever and three of them had dengue hemorrhagic fever. The redox parameters were compared with those of age- and sex- matched controls. No significant difference was observed for levels of GSH and TAS between patients and controls. Levels of PP, MDA + 4-HDA, and SOD were significantly higher. Levels of GPx and total hydroperoxides were significantly lower in patients in comparison with controls. These findings suggest that the alteration in redox status could result of increased oxidative stress and it may play a role in the pathogenesis of the disease.

Received December 19, 2003. Accepted for publication April 27, 2004.

Acknowledgments: We thank Dr. Jean Handy (University of North Carolina, Chapel Hill, NC) and Drs. Ana B. Pérez and Maritza Pupo (Institute of Tropical Medicine Pedro Kouri) for their useful suggestions and comments.

Authors’ addresses: Lizette Gil and Rolando Tápanes, Department of Clinical Pharmacology, Hospital, Institute of Tropical Medicine Pedro Kourí, Havana, Cuba. Gregorio Martínez, College of Pharmacy and Food, Havana University, Havana, Cuba. Osvaldo Castro and Daniel González, Department of Clinical Care, Hospital, Institute of Tropical Medicine Pedro Kourí, Havana, Cuba. Lidice Bernardo, Susana Vázquez, Gustavo Kourí, and María G. Guzmán, Virology Department, Pan American Health Organization/World Health Organization Collaborating Center for Viral Diseases, Institute of Tropical Medicine Pedro Kourí, PO Box 601, Marianao 13, Ciudad de la Havana, Havana, Cuba, Telephone: 53-7-202-0450 and 53-7-202-0633, Fax: 53-7-204-6051, E-mail: lupe{at}ipk.sld.cu.

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