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TREATMENT OF CUTANEOUS GNATHOSTOMIASIS WITH IVERMECTIN

In a randomized open study, we compared the efficacy of a single dose of oral ivermectin (200 µg/kg) and oral albendazole (400 mg/day for 21 days) for the treatment of cutaneous gnathostomiasis. Thirty-one patients were randomly assigned to receive ivermectin (n = 17) or albendazole (n = 14). Thirteen of 17 patients who received ivermectin responded, 3 relapsed, and 1 was unresponsive (cure rate = 76%). Thirteen of 14 patients who received albendazole responded very well and did not relapse. Only one patient was unresponsive (cure rate = 92%; P > 0.05). No major side effects were observed in both groups. We concluded that a single dose of ivermectin (200 µg/kg) is less effective than albendazole (400 mg/day for 21 days) for treatment of cutaneous gnathostomiasis, but there was no statistically significant difference (P > 0.05).

Received February 17, 2004. Accepted for publication May 11, 2004.

Acknowledgments: We thank the government office of the Parasitology Department of Chulalongkorn University for preparation of this report and laboratory assistance. We also thank Associate Professor Phisai Kraivichian, Dr. Satit Kulratana, Paul Alexander Muller, and Poonpat Lohachitranont for their kind hospitality and consent to publish this study.

Financial support: This study was supported by the Asahi Glass Foundation of Japan and the Faculty of Engineering of Chulalonkorn University.

Authors’ addresses: Kanyarat Kraivichian, Surang Nuchprayoon, Prasert Sitichalernchai, and Sutin Yentakam, Department of Parasitology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand, Telephone: 66-2256-4387, Fax 66-2252-4963, E-mail: fmedstt{at}md2.md.chula.ac.th. Wanpen Chaicumpa, Faculty of Allied Health Science, Thammasart University Rangsit Campus, 99 Mu 18, Phaholyothin Road, Klong Luang District, Pathumthani 12121, Thailand, Telephone: 66-2926-9441, 66-2926-9442, Fax 66-2516-5379, E-mail: tmwcc{at}mahidol.ac.th.

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