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Am. J. Trop. Med. Hyg., 71(4), 2004, pp. 478-484
Copyright © 2004 by The American Society of Tropical Medicine and Hygiene

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COMPARISON OF DENGUE-1 VIRUS ENVELOPE GLYCOPROTEIN GENE SEQUENCES FROM FRENCH POLYNESIA

MANOLA LAILLE AND CLAUDINE ROCHE
Laboratoire de Recherche en Virologie Médicale, Institut Louis Malardé, Papeete, Tahiti, Polynésie Française

Dengue (DEN) is the leading arboviral infection of humans, with 100 million cases annually in the tropical areas of the world. The recent severe DEN-1 epidemic in French Polynesia in 2001, with an incidence rate of 16% and more than 45% of the cases with dengue hemorrhagic fever/dengue shock syndrome among 1,400 hospitalized children and eight fatalities, led us to study this new circulating strain. The entire envelope (E) gene of two French Polynesian DEN-1 virus isolates from the two epidemics of 1988–1989 (FP89) and 2001 (FP01) were sequenced and compared with 29 published DEN-1 virus E gene sequences. Phylogenetic relationships showed that the FP89 strain belonged to genotype V and the FP01 strain to genotype IV based on studies on the same region of DEN-1 virus genome (1,485 nucleotides). The recent dengue epidemic in French Polynesia in 2001 was probably due to the introduction of a new DEN-1 virus from Southeast Asia, since the minimum nucleotide divergence was 3.3% with A88, the Indonesian strain isolated in 1988 in Jakarta.

Received October 28, 2003. Accepted for publication May 28, 2004.

We are grateful to Dr. Taiana Darius for help and advice with phylogenetic analysis. We also thank Dr. Allison Imrie for reviewing the manuscript.

Authors’ address: Manola Laille and Claudine Roche, Laboratoire de Recherche en Virologie Médicale, Institut Louis Malardeé, PO Box 30, 98713 Papeete Tahiti, Polynésie Française, Telephone: 689-41-64-68, Fax: 689-43-15-90, E-mails: mlaille{at}ilm.pf and croche{at}ilm.pf.




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Copyright © 2004 by the American Society of Tropical Medicine and Hygiene.