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Am. J. Trop. Med. Hyg., 71(4), 2004, pp. 407-411
Copyright © 2004 by The American Society of Tropical Medicine and Hygiene

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PROTECTION OF C3HEB/FEJ MICE AGAINST LEISHMANIA AMAZONENSIS CHALLENGE AFTER PREVIOUS LEISHMANIA MAJOR INFECTION

YANNICK VANLOUBBEECK AND DOUGLAS E. JONES
Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, Iowa

The Th1 response elicited in mice infected with Leishmania major has been used as a model to characterize cellular immune defects associated with L. amazonensis infection. However, it is not known if the immune response associated with the infection by virulent L. major parasites can promote resistance to a subsequent L. amazonensis infection. Our data demonstrate that C3HeB/FeJ mice infected subcutaneously with virulent L. major are resistant to an L. amazonensis challenge. The healing phenotype is characterized by a Th1 response as measured by increased production of interferon-{gamma} and low levels of interleukin-4 in the draining lymph node. Together, this indicates that the Th1 response associated with L. major infection can promote resistance to L. amazonensis infection and that it can be used as a tool to study the immune defects associated with L. amazonensis infection.

Received December 12, 2003. Accepted for publication June 3, 2004.

Acknowledgments: We thank Dennis Byrne for technical assistance.

Financial support: This work was supported by National Institutes of Health grant AI-48357 and the Biotechnology Council and College of Veterinary Medicine at Iowa State University. Yannick Vanloubbeeck was supported by a Van Roekel scholarship.

Authors’ address: Yannick Vanloubbeeck and Douglas E. Jones, Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, IA 50011-1250, Telephone: 515-294-3282. Fax: 515-294-5423, E-mails: yannick{at}iastate.edu and jonesdou{at}iastate.edu.




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Copyright © 2004 by the American Society of Tropical Medicine and Hygiene.