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EFFICACY OF POST-EXPOSURE TREATMENT OF YELLOW FEVER WITH RIBAVIRIN IN A HAMSTER MODEL OF THE DISEASE

Ribavirin was evaluated as a potential treatment of yellow fever (YF) in a hamster model of the disease. Ribavirin treatment during the first five days after YF virus infection improved survival, reduced tissue damage in target organs (liver and spleen), prevented hepatocellular steatosis, and normalized alanine aminotransferase levels. The results of this study suggest that ribavirin may be effective in the early treatment of YF, and that its mechanism of action in reducing liver pathology in YF virus infection may be similar to that observed with ribavirin in the treatment of chronic hepatitis C virus infection.

Received February 19, 2004. Accepted for publication March 31, 2004.

Acknowledgments: We thank Drs. Ann F. Fisher and Johnson Y. N. Lau for their valuable comments and suggestions, and Dora Salinas for helping in the preparation of the manuscript.

Financial support: This work was supported by National Institutes of Health grant AI-50175 and contract NOI-AI-25489, with financial help from the Food and Drug Administration.

Authors’ address: Elena Sbrana, Shu-Yuan Xiao, Hilda Guzman, Mengyi Ye, Amelia P. A. Travassos da Rosa, and Robert B. Tesh, Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0609, Telephone: 409-747-2431, Fax: 409-747-2429, E-mail: rtesh{at}utmb.edu.

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