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Am. J. Trop. Med. Hyg., 71(2), 2004, pp. 187-189
Copyright © 2004 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT: THE ACTIVITY OF PAMAQUINE, AN 8-AMINOQUINOLINE DRUG, AGAINST SPOROZOITE-INDUCED INFECTIONS OF PLASMODIUM VIVAX (NEW GUINEA STRAINS)

ANTHONY W. SWEENEY, CHARLES R. B. BLACKBURN, AND KARL H. RIECKMANN
Institute for the Biotechnology of Infectious Diseases, University of Technology Sydney, Gore Hill, New South Wales, Australia; Darling Point New South Wales, Australia; Army Malaria Institute, Enoggera, Queensland, Australia

 

ABSTRACT

It was reported in 1946 that the administration of pamaquine during the incubation period delayed but did not prevent primary attacks of a New Guinea strain of Plasmodium vivax malaria. The observation that none of the four test subjects in this study had relapses has not previously been published and may have important implications for the evaluation of other 8-aminoquinoline compounds against relapsing vivax malaria.



Received December 11, 2003. Accepted for publication February 8, 2004.

Authors’ addresses: Anthony W. Sweeney, Institute for the Biotechnology of Infectious Diseases, University of Technology Sydney, Westbourne Street, Gore Hill, New South Wales 2065, Australia, Telephone: 61-2-4385-8774, Fax: 61-2-9514-4003, E-mail: tony. sweeney{at}uts.edu.au. Charles R. B. Blackburn, 64/10 Etham Avenue, Darling Point, New South Wales 2027, Australia, Telephone: 61-2-9363-4816, E-mail: ruthven{at}nd3d.com. Karl H. Rieckmann, Army Malaria Institute, Gallipoli Barracks, Enoggera, Queensland 4052, Australia, Telephone: 61-7-3332-4931, E-mail: Karl.Rieckmann{at}defence.gov.au.

Reprint requests: Anthony W. Sweeney, Institute for the Biotechnology of Infectious Diseases, University of Technology Sydney, West-bourne Street, Gore Hill, New South Wales 2065, Australia.




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Copyright © 2004 by the American Society of Tropical Medicine and Hygiene.