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SEROPREVALENCE OF IgG SPECIFIC FOR DENGUE VIRUS AMONG ADULTS AND CHILDREN IN SANTO DOMINGO, DOMINICAN REPUBLIC

The seroprevalence of dengue (DEN) virus-specific IgG was determined by enzyme-linked immunosorbent assay among 1,008 adults recruited at blood banks and among 201 children less than 10 years old visiting a hospital in Santo Domingo, Dominican Republic. Most (98%, 987 of 1,008) of the adults and 56% (113 of 201) of the children were positive for DEN virus-specific IgG. Among adults, there were no significant differences in the prevalence by age, sex, and residential area of the participants. Among children, the prevalence of DEN virus-specific IgG increased with age (1–2 years old, 0–5%; 3–6 years old, 25–65%; and 7 years old, 76–92%). The prevalence in 50% of those less than one year of age was probably due to maternal antibody transfer. Neutralization tests of adult samples indicate that DEN virus infections with different serotypes have occurred sequentially or simultaneously among the inhabitants of Santo Domingo.

Received August 6, 2003. Accepted for publication February 9, 2004.

Authors’ addresses: Tetsu Yamashiro, Institute of Scientific Research, Faculty of Medicine, Oita University, Hasama-machi, Oita 879-5593, Japan, Telephone: 81-97-586-5712, Fax: 81-97-586-5719, E-mail: tetyam{at}med.oita-u.ac.jp. Mildre Disla, Angela Petit, Delfis Taveras, Mercedez Castro-Bello, Miguel Lora-Orste, Sonia Vardez, Ana Julia Cesin, and Barbara Garcia, Centro de Educación Médica de Amistad Dominico-Japonesa, Calle Federico Velazquez No.1, María Auxiladora, Santo Domingo, Dominican Republic, Telephone: 809-684-0411, Fax: 809-245-5148. Akira Nishizono, Department of Infectious Diseases, Faculty of Medicine, Oita University, Hasama-machi, Oita 879-5593, Japan, Telephone: 81-97-586-5712, Fax: 81-97-586-5719, E-mail: a24zono{at}oita-med.ac.jp.

Reprint requests: Tetsu Yamashiro, Institute of Scientific Research, Faculty of Medicine, Oita University, Hasama-machi, Oita 879-5593, Japan, Telephone: 81-97-586-5712, Fax: 81-97-586-5719.