AJTMH ASTMH Job Mart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 71(1), 2004, pp. 40-42
Copyright © 2004 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (5)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by HUAMAN, M. C.
Right arrow Articles by KANBARA, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by HUAMAN, M. C.
Right arrow Articles by KANBARA, H.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*CHLOROQUINE
Related Collections
Right arrow Drug-Resistance
Right arrow Plasmodium

SHORT REPORT: POLYMORPHISMS IN THE CHLOROQUINE RESISTANCE TRANSPORTER GENE IN PLASMODIUM FALCIPARUM ISOLATES FROM LOMBOK, INDONESIA

MARIA CECILIA HUAMAN, KAZUMI YOSHINAGA, AAN SURYANATHA, NYOMAN SUARSANA, AND HIROJI KANBARA
Institute of Tropical Medicine, Nagasaki University, Sakamoto, Nagasaki, Japan; Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru; Meninting Health Center, West Lombok, Indonesia

 

ABSTRACT

The polymorphisms in the Plasmodium falciparum multidrug resistance 1 (pfmdr1) and P. falciparum chloroquine resistance transporter (pfcrt) genes, which are associated with chloroquine resistance, were examined in 48 P. falciparum isolates from uncomplicated malaria patients from the West Lombok District in Indonesia. The point mutation N86Y in pfmdr1 was present in 35.4% of the isolates and mutation K76T in pfcrt was found in all but one of the samples studied. Identified pfcrt haplotypes were mainly identical to the Papua New Guinea type SagtVMNT (42 of 48, 87.5%), and a few isolates had the Southeast Asia type CVIET (5 of 48, 10.4%). Moreover, one P. falciparum isolate harbored the K76N mutation, giving rise to the haplotype CVMNN, which was not previously reported in field isolates. Our findings suggest that chloroquine resistance in this area might have the same origin as in Papua New Guinea.

Received December 16, 2003. Accepted for publication February 4, 2004.

Acknowledgments: We are grateful to the Case Detection and Treatment Team at the Meninting Health Center (West Lombok, Indonesia) for their collaboration in this study.

Financial support: This study was partially supported by the Japanese International Cooperation Agency partnership program, and by grant for International Health Cooperation Research (13-C-5) from the Ministry of Health, Labor and Welfare. Maria Cecilia Huaman is the recipient of the Monbusho scholarship awarded by the Ministry of Education, Science, Sports and Culture of the Government of Japan.

Authors’ addresses: Maria Cecilia Huaman, Institute of Tropical Medicine, Nagasaki University, Sakamoto 1-12-4, Nagasaki 852-8523, Japan and Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru, E-mail: ceci_ huaman{at}yahoo.com. Kazumi Yoshinaga and Hiroji Kanbara, Institute of Tropical Medicine, Nagasaki University, Sakamoto 1-12-4, Nagasaki 852-8523, Japan, Telephone: 81-95-849-7838, Fax: 81-95-849-7805. E-mail: f0512{at}cc.nagasaki-u.ac.jp. Aan Suryanatha and Nyoman Suarsana, Meninting Health Center, West Lombok, Indonesia.




This article has been cited by other articles:


Home page
 Am J Trop Med HygHome page
Y. Saito-Nakano, K. Tanabe, K. Kamei, M. Iwagami, K. Komaki-Yasuda, S.-i. Kawazu, S. Kano, H. Ohmae, and T. Endo
Genetic Evidence for Plasmodium falciparum Resistance to Chloroquine and Pyrimethamine in Indochina and the Western Pacific between 1984 and 1998
Am J Trop Med Hyg, October 1, 2008; 79(4): 613 - 619.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2004 by the American Society of Tropical Medicine and Hygiene.