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Am. J. Trop. Med. Hyg., 70(6), 2004, pp. 635-637
Copyright © 2004 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT: HIGH PREVALENCE OF MULTIDRUG-RESISTANT PLASMODIUM FALCIPARUM MALARIA IN THE FRENCH TERRITORY OF MAYOTTE

FRANÇOIS PETTINELLI, MARIE-EDITH PETTINELLI, PHILIPPE ELDIN DE PÉCOULAS, JULIE MILLET, DELPHINE MICHEL, PHILIPPE BRASSEUR, AND PIERRE DRUILHE
Centre Hospitalier de Mayotte, Mamoudzou, Mayotte; Faculté de Médecine, Rouen, France; Unité de Parasitologie Bio-Médicale, Institut Pasteur, Paris, France

 

ABSTRACT

A drug-resistance survey was conducted in the French territory of Mayotte in the Comorian Islands in the Indian Ocean where malaria is endemic. A high prevalence of resistant Plasmodium falciparum parasites was observed, not only to chloroquine (88%) and pyrimethamine (99%), but more surprisingly to quinine (17%), mefloquine (9%), and amodiaquine (24%). This leaves few treatment alternatives other than artemisine-mefloquine combinations. However, despite notification to French Health authorities three years ago, inadequate treatment (chloroquine plus sulfadoxine-pyrimethamine) is still used in this locality. Thus, people still die of malaria in this remote territory of France.

Received September 4, 2003. Accepted for publication December 18, 2003.

Authors’ addresses: François Pettinelli, Marie-Edith Pettinelli, Julie Millet, and Delphine Michel, Centre Hospitalier de Mayotte, 97600 Mamoudzou, Mayotte. Philippe Eldin de Pécoulas and Philippe Brasseur, Faculté de Médecine, 22, Boulevard Gambetta, 76183 Rouen, France. Pierre Druilhe, Unité de Parasitologie Bio-Médicale, Institut Pasteur, 75015 Paris, France.

Reprint requests: Pierre Druilhe, Unité de Parasitologie BioMédicale, Institut Pasteur, 25 Rue du Dr Roux, 75015 Paris, France, Telephone: 33-1-45-68-85-78, Fax: 33-1-45-68-86-40, E-mail: druilhe{at}pasteur.fr.




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