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Am. J. Trop. Med. Hyg., 70(5), 2004, pp. 576-579
Copyright © 2004 by The American Society of Tropical Medicine and Hygiene

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COMPARISON OF THE EFFECTIVENESS OF FIVE DIFFERENT ANTIBIOTIC REGIMENS ON INFECTION WITH RICKETTSIA TYPHI: THERAPEUTIC DATA FROM 87 CASES

ACHILLEAS GIKAS, STEPHANOS DOUKAKIS, JOHN PEDIADITIS, SERAFIM KASTANAKIS, ANDREAS MANIOS, AND YIANNIS TSELENTIS
Clinical Bacteriology, Parasitology Zoonoses, and Geographic Medicine, University Hospital of Heraklion, Heraklion, Crete, Greece, World Health Organization Collaborating Center, Herakion, Crete, Greece; Department of Internal Medicine, General Hospital of Chania, Chania, Crete, Greece

This study estimated the clinical effectiveness of five different antibiotic regimens (doxycycline, chloramphenicol, ciprofloxacin, doxycycline plus chloramphenicol, and doxycycline plus ciprofloxacin) administered for infection with Rickettsia typhi in terms of the duration of the fever. Eighty-seven patients with endemic typhus were hospitalized between 1993 and 1998 at the General Hospital of Chania in Chania, Crete, Greece. The mean time to defervescence was 2.9 days for doxycycline, 4.0 days for chloramphenicol, and 4.2 days for ciprofloxacin. In patients receiving combinations of doxycycline plus chloramphenicol and doxycycline plus ciprofloxacin, fever subsided in 3.4 and 4.0 days, respectively. The outcome was favorable in all patients, and no deaths or relapses were observed within two months.

Received July 5, 2003. Accepted for publication September 25, 2003.

Authors’ addresses: Achilleas Gikas and Yiannis Tselentis, Clinical Bacteriology, Parasitology Zoonoses, and Geographic Medicine, University Hospital of Heraklion, PO Box 1352, Heraklion, Crete, Greece, E-mail: gikas{at}med.uoc.gr. Stephanos Doukakis and Serafim Kastanakis, Department of Internal Medicine, General Hospital of Chania, Chania, Crete, Greece. John Pediaditis, Levinou 64-66, 71304 Heraklion, Crete, Greece. Andreas Manios, 7 Dimokratias Avenue, 71306 Heraklion, Crete, Greece.






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Copyright © 2004 by the American Society of Tropical Medicine and Hygiene.