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The Development of a Pyrimethamine-Resistant Line of Toxoplasma under in Vitro Conditions¹

1. A pyrimethamine-resistant line of Toxoplasma at least 640 times more resistant than the parent strain was developed in vitro.

2. The resistant nature of this line was retained for at least 3 months when the parasite was grown in the absence of pyrimethamine.

3. A pyrimethamine-requiring line of Toxoplasma could not be developed.

4. The drug-resistant nature of this line of Toxoplasma was not demonstrable in vivo.

¹ A portion of a dissertation submitted to the George Washington University in partial satisfaction of the requirements for the degree of Doctor of Philosophy.

² Present address: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases.

³ Laboratory of Tropical Diseases.

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