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Biology of the Treponematoses

by THOMAS BOURNE TURNER, Professor of Microbiology, Johns Hopkins University, Baltimore, Md., U. S. A., AND DAVID H. HOLLANDER, Assistant Professor of Microbiology, Johns Hopkins University, Baltimore, Md., U. S. A. Based on Studies Carried Out at the International Treponematosis Laboratory Center of the Johns Hopkins University under the Auspices of the World Health Organization. World Health Organization Monograph Series No. 35 World Health Organization, Geneva, 1957

With the recognition of the fact that the treponemal diseases are a major world health problem, this monograph on the Biology of the Treponematoses is an outstanding contribution to medicine.

The fundamental biology of the treponematoses is surveyed in the first six chapters which discuss the treponemal strains investigated and the methods of isolation; pathogenesis in laboratory animals; in vitro characteristics of the organisms, the immune reactions to treponemes; and the in vitro and in vivo effect of drugs.

Interesting comparisons of the various strains and species of treponemes are made in the next three chapters. Comparisons of disease produced in laboratory animals, immune responses and antigenic relationship, and response of various strains to penicillin were studied in an attempt to establish strain identity.

The authors have thus demonstrated close relationship of treponemal strains from syphilis, yaws, bejel and other endemic syphilis syndromes, particularly as to drug response, immune reactions, and pathogenesis.