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Am. J. Trop. Med. Hyg., 7(3), 1958, pp. 329-333
Copyright © 1958 by The American Society of Tropical Medicine and Hygiene

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Therapy of Trichuriasis and Ascariasis with Dithiazanine1

J. C. Swartzwelder2, R. Lampert, J. H. Miller, R. W. Sappenfield, W. W. Frye, S. H. Abadie AND L. J. Coco
Louisiana State University School of Medicine, New Orleans; Charity Hospital of Louisiana, New Orleans; and State Colony and Training School, Pineville, Louisiana

Dithiasanine is an effective, oral, therapeutic agent for clinical and subclinical trichuriasis. This new anthelmintic is useful for mass therapy for trichuriasis. Since dithiazanine also has significant anthelmintic activity against A. lumbricoides, it is suitable for the treatment of mixed infections of trichuriasis and ascariasis, two helminthiases which frequently coexist in persons in endemic areas. An effective dosage of this drug for the therapy of trichuriasis and/or ascariasis is 20 mg per lb, with a maximum of 600 mg per day given in divided doses 3 times daily (i.e., 200 mg t.i.d.), for 5 or more days depending upon the size and severity of the infection. No serious side effects have occurred in several hundred children and adults treated with this anthelmintic.


1 This investigation was supported in part by research grant E-543 from the National Institute of Allergy and Infectious Diseases, of the National Institutes of Health, Public Health Service.

The drug employed in this study, dithiazanine, was supplied by Eli Lilly and Co.


2 Address: 1542 Tulane Avenue, New Orleans 12, Louisiana.






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Copyright © 1958 by the American Society of Tropical Medicine and Hygiene.