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Attempts to Produce Immunity against the Filarial Worms of Cotton Rats by Transfer of Developing Worms¹

When fourth stage larvae or young adult worms of Litomosoides carinii are introduced surgically into the abdominal cavity of cotton rats, there is a retardation of growth and development of worms of a subsequent superimposed infection induced by subcutaneous introduction of infective larvae. This retardation is not so great, however, as when the primary infection is produced by subcutaneous introduction of infective larvae. Furthermore no effect is produced unless the number of fourth stage or adult worms is considerably larger than the minimum number of infective larvae required to produce this effect.

¹ This investigation was supported in part by Research Grant E 64 from the National Institutes of Health, U. S. Public Health Service.