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Effects of Phthalofyne¹ in the Treatment of Human Trichuris Trichiura Infection

Phthalofyne (3-methyl-1-pentyn-3-yl acid phthalate), a synthetic chemical compound demonstrated to have trichuricidal activity against both Trichuris vulpis and Trichuris trichiura, was given to 10 healthy young Filipino males harboring Trichuris trichiura. Of 7 cases who received 100 to 125 mg./kg. by mouth, alone or in combination with the same dose given by enema, 4 had rather minimal complaints of nausea and/or vomiting and none received significant therapeutic benefit. The highest oral dose, 175 mg./kg. given to a single patient, produced considerable nausea and apparently complete regurgitation of gastric contents and no therapeutic benefit, suggesting that effective single oral doses would not be easily retained. The phthalofyne enemas, containing respectively 200 mg./kg. and 450 mg./kg. of the drug, and given one week apart to a single patient, produced no side effects and no significant therapeutic effect.

The simultaneous administration of 145 mg./kg. by mouth and 450 mg./kg. by enema resulted in moderately severe toxic effects including generalized malaise, nausea and vomiting, conjunctivitis, keratitis, and impaired auditory and visual acuity, all of which subsided within one to several days. In the one case so treated, Trichuris eggs were absent from the stools during a period of several days after therapy, though eggs were found in 1 of 3 stool specimens examined 6 weeks after therapy.

¹ Phthalofyne (Whipcide) and phthalofyne acid (P-403A) produced by Pitman-Moore Company, Indianapolis, Indiana, were kindly furnished for this study through the courtesy of Dr. Carl A. Bunde.