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Observations on Resistance to Sulfadiazine and Antibiotics in Shigellosis

Combined bacteriological and clinical studies were undertaken to determine the sensitivity of Shigella to sulfadiazine and antibiotics. About 50 per cent of the strains of Shigella examined were resistant to sulfadiazine in vitro, and a similar lack of response to treatment with this drug was observed in cases caused by resistant strains. While chloramphenicol was the drug of choice in sulfa-resistant shigellosis until 1955, strains were isolated in 1956 which proved to be resistant to chloramphenicol and the tetracyclines. A number of cases of acute shigellosis caused by such resistant strains took a clinically severe course and some of them died.

The need for planned treatment of bacillary dysentery is indicated by the above findings, and the introduction of drugs like neomycin or polymyxin, which were found to be very effective in vitro in the treatment of cases caused by resistant strains, must be taken into consideration.

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				H. A. REIMANN Infectious Diseases: Annual Review of Significant Publications Arch Intern Med, July 1, 1959; 104(1): 108 - 151. [Abstract] [PDF]