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Am. J. Trop. Med. Hyg., 69(5), 2003, pp. 553-554
Copyright © 2003 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT: IN VIVO SENSITIVITY OF PLASMODIUM FALCIPARUM TO HALOFANTRINE IN SOUTHERN CENTRAL VIETNAM

DOAN HANH NHAN, WALTER R. J. TAYLOR, NGUYEN DIEU THUONG, TRAN THI UYEN, DAVID J. FRYAUFF, IKA SUSANTI, EDUARDO GÓMEZ-SALADÍN, LE DINH CONG, AND J. KEVIN BAIRD
U. S. Naval Medical Research Unit No. 2, Jakarta, Indonesia; Department of Tropical Medicine, Tulane University School of Public Health, New Orleans, Louisiana; Institute of Malariology, Parasitology, and Entomology, Hanoi, Vietnam

 

ABSTRACT

Drug-resistant Plasmodium falciparum is present in Vietnam. We assessed the in vivo sensitivity of P. falciparum to halofantrine in two villages in the southern part of central Vietnam. Halofantrine (8 mg/kg x 3 doses) was administered to 37 patients with either P. falciparum (n = 32) or mixed P. falciparum/P. vivax malaria (n = 5). End points were parasite sensitivity or resistance (RI/RII/RIII) determined by parasite clearance, persistence, or recurrence during 28 days of follow-up. By day 28, 31 (93.9%) of 33 (95% confidence interval = 79.8–99.2%) patients were sensitive. Two patients had recurrent P. falciparum parasitemia on days 14 and 21. Halofantrine effectively treated uncomplicated P. falciparum malaria in these Vietnamese patients.

Received September 17, 2002. Accepted for publication April 26, 2003.

Acknowledgments: We are grateful to Drs. Luc Nguyen Tuyen (Khanh Hoa Provincial Antimalaria Office, Nha Trang, Vietnam), Le Minh Dao and Ta Thi Tinh (Institute of Malariology, Parasitology, and Entomology, Hanoi, Vietnam) for assistance with field execution; Pak Suradi (U.S. Naval Medical Research Unit No. 2) for assistance with data management; and Pak Purnomo and Pak Masbar for slide quality control.

Financial support: This study was supported by the U.S. Naval Medical Research and Development Command (Work Unit Number 63002A810.00101.HFX.1433).

Disclaimer: The views expressed in this article are those of the authors and do not in any way represent those of the U.S. Navy or the Vietnamese Ministry of Health.

Authors’ addresses: Doan Hanh Nhan, Nguyen Dieu Thuong, Tran Thi Uyen, and Le Dinh Cong, Institute of Malariology, Parasitology, and Entomology, Hanoi, Vietnam. Walter R. J. Taylor, World Health Organization/TDR/PRD, Centre Casai, 51-53 Avenue Louis, Casai 1216, Cointrin, Geneva, Switzerland, Telephone: 41-22-791-3853, Fax: 44-22-791-4774, E-mail: taylorw{at}who.ch. David J. Fryauff, Ika Susanti, Eduardo Gómez-Saladín, and J. Kevin Baird, U.S. Naval Medical Research Unit No. 2, Box 3, Unit 8132, APO, AP 96520-8132, Jakarta. Indonesia.






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Copyright © 2003 by the American Society of Tropical Medicine and Hygiene.