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Am. J. Trop. Med. Hyg., 69(3), 2003, pp. 269-276
Copyright © 2003 by The American Society of Tropical Medicine and Hygiene

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INDUCTION OF SEVERE DISEASE IN HAMSTERS BY TWO SANDFLY FEVER GROUP VIRUSES, PUNTA TORO AND GABEK FOREST (PHLEBOVIRUS, BUNYAVIRIDAE), SIMILAR TO THAT CAUSED BY RIFT VALLEY FEVER VIRUS

ANN F. FISHER, ROBERT B. TESH, JESSICA TONRY, HILDA GUZMAN, DONGYING LIU, AND SHU-YUAN XIAO
Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, and Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas

Adult golden hamsters inoculated subcutaneously with either of two sandfly fever group viruses, Punta Toro and Gabek Forest (Phlebovirus, Bunyaviridae), developed a fulminating fatal illness characterized by hepatic and splenic necrosis and interstitial pneumonitis. Most animals died within three days after infection; this was accompanied by high levels of viremia. Necropsy and histopathologic examination of the infected animals revealed pathologic changes involving multiple organs that resembled those described in Rift Valley fever. These two hamster-phlebovirus systems may serve as alternative animal models for Rift Valley fever and should be useful in studying the pathogenesis of severe phlebovirus infection and for testing potential therapeutic agents.

Received February 27, 2003. Accepted for publication May 27, 2003.

Financial support: This study was supported by the National Institutes of Health (grants AI-10984 and AI-50175 and contract NO1-AI-25489). Ann F. Fisher was supported by a National Institutes of Health T32 training grant in Emerging and Re-emerging Infectious Disease (AI-07536).

Authors’ addresses: Ann F. Fisher, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555-0588. Robert B. Tesh, Jessica Tonry, Hilda Guzman, and Dongying Liu, Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555-0588. Shu-Yuan Xiao, Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, and Department of Internal Medicine, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0588, Telephone: 409-772-8447, Fax: 409-772-4676, E-mail: syxiao{at}utmb.edu.




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