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The NOW® ICT Malaria P.f./P.v. for Whole Blood (Binax, Inc., Portland, ME) is a new malaria rapid diagnostic device that represents a technical advance over previous assays, such as ICTTM Malaria P.f./P.v. and ICTTM Malaria P.f.. We evaluated this device in March 2001 in symptomatic patients at malaria clinics in Maesod, Thailand. Microscopic examination of Giemsa-stained blood smears was the reference standard. In 246 patients, microscopy showed 32 (13.0%) infected with Plasmodium falciparum, 63 (25.6%) with P. vivax, 6 (2.4%) with mixed infections of P. falciparum and P. vivax, 5 (2.0%) with P. malariae, and 140 (56.9%) negative. Sensitivity for P. falciparum was 100% and specificity was 96.2% (200 of 208; 95% confidence interval [CI] = 92–98). For P. vivax, sensitivity was 87.3% (55 of 63; 95% CI = 77–93) and specificity was 97.7% (173 of 177; 95% CI = 95–99), but all the four false-positive results were microscopically positive for P. malariae; thus, specificity for non-falciparum Plasmodium was 100%. These results suggest improved performance over NOW® ICT predecessors.
Received January 23, 2003. Accepted for publication April 2, 2003.
Acknowledgments: We are grateful to Dr. J. Sirichaisinthop of the Thai Ministry of Public Health for his support and to the AFRIMS Malaria Field Team for their technical assistance.
Financial support: The study was supported by the U.S. Army Medical Materiel Development Activity (Fort Detrick, Frederick, MD).
Disclaimer: The views expressed are those of the authors and should not be construed to represent the positions of the Department of the Army, Department of the Air Force, or Department of Defense.
Authors’ addresses: Chansuda Wongsrichanalai, United States Naval Medical Research Unit No. 2, Kompleks P2M/PLP-LITBANGKES, Jalan Percetakan Negara No. 29, Jakarta 10570, Indonesia, Telephone: 62-21-421-4457 extension 1230, Fax: 62-21-420-7854, E-mail: chansuda{at}namru2.med.navy.mil. Iracema Arevalo, Alan J. Magill, and Robert A. Gasser, Jr.: Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910-7500. Anintita Laoboonchai, Kritsanai Yingyuen, and R. Scott Miller: Department of Immunology and Medicine, Armed Forces Research Institute of Medical Sciences, 315/6 Rajvithi Road, Bangkok 10400, Thailand. J. Russ Forney: ATTN: MADN-CHEM, United States Military Academy, Official Mail and Distribution Center, 646 Swift Road, West Point, NY 10996-1905.
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