HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (8) Citing Articles via Google Scholar Google Scholar Articles by GONÇALVES, D. U. Articles by LAMBERTUCCI, J. R. Search for Related Content PubMed PubMed Citation Articles by GONÇALVES, D. U. Articles by LAMBERTUCCI, J. R. Pubmed/NCBI databases Medline Plus Health Information Skin Conditions Related Collections AIDS

DERMATOLOGIC LESIONS IN ASYMPTOMATIC BLOOD DONORS SEROPOSITIVE FOR HUMAN T CELL LYMPHOTROPIC VIRUS TYPE-1

Dermatologic manifestations are quite common in patients with adult T cell leukemia/lymphoma and myelopathy/tropical spastic paraparesis associated with infection with human T cell lymphotropic virus type-1 (HTLV-1). In this study, we evaluated the dermatologic lesions of eligible blood donors in the state of Minas Gerais in Brazil who were seropositive but asymptomatic for infection with HTLV-1. The study population was composed of 128 HTLV-1-seropositive individuals and 108 seronegative controls. All individuals underwent a dermatologic evaluation. Biopsy specimens were obtained from abnormal and normal skin samples of seropositive individuals in an attempt to detect HTLV-1 in tissue samples by a polymerase chain reaction. Dermatologic alterations were observed more frequently in the seropositive group (adjusted odds ratio [OR] = 8.77, 95% confidence interval [CI] = 4.11–18.71). The most common skin diseases were dermatophytoses (adjusted OR = 3.32, 95% CI = 1.50–7.35), seborrheic dermatitis (OR = 3.53, 95% CI = 0.67–24.66), and acquired ichthyosis (P = 0.001). Virus was detected more frequently in abnormal skin samples. Dermatologic lesions probably related to HTLV-1 infection were diagnosed in eligible blood donors who were infected with this virus, who were previously considered to be asymptomatic carriers of HTLV-1.

Received June 11, 2002. Accepted for publication February 13, 2003.

Acknowledgments: We thank all members of the Interdisciplinary HTLV-1/2 Research Group, especially, Bernadete Catalan Soares, Olindo de Assis Martins Filho, Sônia Regina Pinheiro and João Gabriel Ribas, for their participation in the study.

Financial support: This work was partially supported by the Brazilian National Research Council (CNPp/Brazil) and the Foundation for Research Support of the state of Minas Gerais (FAPEMIG/MG).

Authors’ addresses: Denise Utsch Gonçalves, Antonio Carlos Martins Guedes, Fernando Augusto Proietti, and José Roberto Lambertucci, Departamento de Clínica Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Avenida Alfredo Balena, 190, 4° Andar, CEP 30130-100, Belo Horizonte, Minas Gerais, Brazil, Telephone: 55-31-3248-9821, Fax: 55-31-3248-9820, E-mail: lamber{at}net.em.com.br. Anna Bárbara de Freitas Carneiro Proeitti, Fundação Hemominas, Minas Gerais State Center of Hematology and Hemotherapy, Alameda Ezequiel Dias, 321, CEP 30180-100, Belo Horizonte, Minas Gerais, Brazil, Telephone: 55-31-3226-2002. Marina Lobato Martins, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, Pampulha. CEP 31270-010, Belo Horizonte, Minas Gerais, Brazil, Telephone: 55-31-3499-2873.

This article has been cited by other articles:

				H. Kwon, L. Ogle, B. Benitez, J. Bohuslav, M. Montano, D. W. Felsher, and W. C. Greene Lethal Cutaneous Disease in Transgenic Mice Conditionally Expressing Type I Human T Cell Leukemia Virus Tax J. Biol. Chem., October 21, 2005; 280(42): 35713 - 35722. [Abstract] [Full Text] [PDF]