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Am. J. Trop. Med. Hyg., 68(4 suppl), 2003, pp. 3-9
Copyright © 2003 by The American Society of Tropical Medicine and Hygiene

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THE EFFICACY OF PERMETHRIN-TREATED BED NETS ON CHILD MORTALITY AND MORBIDITY IN WESTERN KENYA I. DEVELOPMENT OF INFRASTRUCTURE AND DESCRIPTION OF STUDY SITE

PENELOPE A. PHILLIPS-HOWARD, BERNARD L. NAHLEN, JANE A. ALAII, FEIKO O. TER KUILE, JOHN E. GIMNIG, DIANNE J. TERLOUW, S. PATRICK KACHUR, ALLEN W. HIGHTOWER, ALTAF A. LAL, ERIK SCHOUTE, AGGREY J. OLOO, AND WILLIAM A. HAWLEY
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; Centre for Vector Biology and Control Research, Kenya Medical Research Institute, Kisumu, Kenya; Department of Infectious Diseases, Tropical Medicine & AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Randomized controlled trials in sub-Saharan Africa have shown that permethrin-treated bed nets and curtains reduce all-cause child mortality by 15–33% in areas with low or high but seasonal malaria transmission. This report describes the study site for a community-based, group-randomized, controlled trial in an area of high and year-round malaria transmission in western Kenya. We outline the development of the human and physical infrastructure required to conduct this trial and discuss some of the difficulties encountered and lessons learned in conducting it.

Acknowledgments: We thank the villagers of Asembo and Gem for their participation, and the field and administrative staff for their assistance in developing the infrastructure for this study. This paper has been published with the permission of the Director of the Kenya Medical Research Institute.

Financial support: The ITN project was funded by the United States Agency for International Development.

Disclaimer: The opinions or assertions contained in this manuscript are the private ones of the authors and are not to be construed as official or reflecting the views of the U.S. Public Health Service or Department of Health and Human Services. Use of trade names is for identification only and does not imply endorsement by the U.S. Public Health Service or Department of Health and Human Services.

Authors’ addresses: Penelope A. Phillips-Howard, Feiko O. ter Kuile, John E. Gimnig, Dianne J. Terlouw, S. Patrick Kachur, Allen W. Hightower, Altaf A. Lal, and William A. Hawley, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Mailstop F-22, 4770 Buford Highway, Atlanta, GA 30341. Bernard L. Nahlen, Roll Back Malaria, World Health Organization, Avenue Appia 20, 1211 Geneva 27, Switzerland. Jane A. Alaii, Erik Schoute, and Aggrey J. Oloo, Centre for Vector Biology and Control Research, Kenya Medical Research Institute, PO Box 1578, Kisumu, Kenya.




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