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PREVALENCE OF RELATIVE BRADYCARDIA IN ORIENTIA TSUTSUGAMUSHI INFECTION

We investigated 100 febrile patients infected with Orientia tsutsugamushi (the etiologic agent of scrub typhus) for the presence of relative bradycardia, defined as in increase in heart rate of < 10 beats/minutes/1°C increase in temperature. The median heart rate response for the entire febrile scrub typhus population was 9.3 beats/minute/°C and the prevalence of relative bradycardia was 53%. The occurrence of relative bradycardia was independent of patient age or gender. There were no differences in median basal temperature or febrile temperature between those patients exhibiting relative bradycardia and those with a normal febrile pulse increase. However, febrile patients with relative bradycardia had a significantly higher resting pulse rate following recovery from infection than did patients who had a normal pulse increase during their illness. These data demonstrate that relative bradycardia frequently accompanies mild infection with O. tsutsugamushi and that baseline cardiovascular parameters may affect the febrile heart rate response to scrub typhus.

Received October 2, 2002. Accepted for publication January 9, 2003.

Acknowledgment: This work was presented in part at the 40th Annual Meeting of the Infectious Diseases Society of America, Chicago, October 2002.

Financial support: This study was supported by the U.S. Army Research and Material Command and the Royal Thai Army.

Disclaimer: The opinions or assertions contained in this report are the private views of the investigators and are not to be construed as official or reflecting the views of the U.S. Army or the Royal Thai Army.

Authors’ addresses: David M. Aronoff, Divisions of Infectious Diseases and Pulmonary and Critical Care Medicine, University of Michigan Health System, 6301 MSRB III, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-0642, Telephone: 734-763-9077, Fax: 734-764-4556, E-mail: daronoff{at}umich.edu. George Watt, HIV Interaction Section, Retrovirology Department, Armed Forces Research Institute of Medical Sciences, APO AP 96546, Telephone: 66-2-644-6735, Fax: 66-2-246-8908, E-mail: wattgh{at}thai.amedd.army.mil or gwattth{at}yahoo.com

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