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Am. J. Trop. Med. Hyg., 68(3), 2003, pp. 376-378
Copyright © 2003 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT: ANALYSIS OF ANTI-MALARIA IMMUNE RESPONSE DURING HUMAN IMMUNODEFICIENCY VIRUS INFECTION IN ADULTS IN KINSHASA, DEMOCRATIC REPUBLIC OF THE CONGO

M. KASHAMUKA, N. NZILA, L. MUSSEY, N. LUBAKI, T. C. QUINN, R. BOLLINGER, AND N. KUMAR
Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Merck & Co., Inc., Blue Bell, Project SIDA, PNLS/NRL/Hopital General de Kinshasa, Democratic Republic of the Congo

 

ABSTRACT

Co-infection of human immunodeficiency virus and malaria is not uncommon in people living in sub-Saharan Africa. Since HIV infection results in immune deficiency, it may alter the ability of HIV patients to mount proper immune responses against malaria parasites. We measured specific malaria antibodies in 47 specimens from 25 couples from Kinshasa, Democratic Republic of the Congo (DRC), according to their HIV status, and investigated probable interaction between malaria and HIV infection. Plasma samples were analyzed for HIV markers (western blot and viral load) and malaria parasite-specific antibody (antibody titer, pattern of antigen recognized by western blotting, and parasite neutralizing antibodies assayed by growth inhibition). No correlation was identified between measured HIV infection status and malaria-specific parameters.

Received August 27, 2002. Accepted for publication October 30, 2002.

Acknowledgments: We thank all participants in this study and Cevayir Coban, Darin Kongkasuriyachai, Mobolaji Okulate, Mrinal Bhattacharyya, Sheila Keating, and Steven Renold for their help during these studies and Sabra Klein for help with statistical analysis. We also thank our colleagues from Project SIDA, especially Atibu Losoma, Milangu and Lelo for their contributions to collecting and processing specimens used in the study.

Financial support: This work was supported by grants to Johns Hopkins University from the Fogarty International Center of the U.S. National Institutes of Health (2-D 43 TW000010-AITRP) and the National Institutes of Allergy and Infectious Diseases, NIH (R03 AI 45119).

Authors’ addresses: M. Kashamuka and N. Nzila, Project SIDA, PNLS/NRL/Hopital General de Kinshasa, Pavillion 27 BP 8502, Democratic Republic of the Congo and Division of Infectious Diseases, Johns Hopkins University School of Medicine. L. Mussey, Merck & Company, Inc., 795 Jolly Road, UN-C141, Blue Bell, PA, 19422. N. Lubaki, T. C. Quinn and R. Bollinger, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Ross Research Building, 720 Rutland Avenue, Baltimore, MD 21205. N. Kumar, Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD, 21205.

Reprint requests: Dr. Nirbhay Kumar, E5144, MMI, BSPH, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, Telephone: 410-955-7177, Fax: 410-955-0105, E-mail: nkumar{at}jhsph.edu






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Copyright © 2003 by the American Society of Tropical Medicine and Hygiene.